482 



Mr. W. H. Jessop. 



[June 10, 



8. On cocaine mydriasis section of the cervical sympathetic had no 

 effect. 



9. In cases of ad maximum cocaine mydriasis, stimulation of the 

 cervical sympathetic had no effect. 



10. In cases of section for some time of cervical sympathetic cocaine 

 has no effect on the pupil. 



11. On tapping the anterior chamber of an eye under cocaine there 

 is very little and often no constriction of the pupil. 



From these data we may conclude that cocaine acts on the endings 

 of the cervical sympathetic nerve in the eye. 



B. On the Ciliary Muscle. — Cocaine on the ciliary muscle produces 

 relaxation and paresis, or in some cases paralysis of accommodation, 

 and it is reasonable to suppose from analogy that it acts here on the 

 endings of the fifth nerve to the muscle. 



Atropine. A. On the Pupil. — 1. Atropine produces, in mammals, 

 mydriasis not acting to light and accommodation. 



2. It has no effect on the pupils of birds. 



3. It only produces a partial mydriasis in rabbits. 



4. It increases the mydriasis produced by section of the third 

 nerve, or the short ciliary nerves. 



5. Stimulation of the third nerve has no effect on an atropinised pupil. 



6. The myosis due to section of the cervical sympathetic is Over- 

 come and mydriasis produced by atropine ; this seen even after section 

 for three months in a rabbit. 



7. Section of the cervical sympathetic diminishes slightly atropine 

 mydriasis. 



8. Stimulation of the cervical sympathetic increases atropine 

 mydriasis. 



9. Atropine dilates the pupil after excision of the superior cervical 

 ganglion. 



10. Atropine mydriasis increased by stimulating one or more of the 

 long ciliary nerves. 



11. Atropine mydriasis increased by faradaising the periphery of 

 the cornea. 



12. Atropine mydriasis diminished somewhat by cutting the 

 trigeminus. 



13. Section of the trigeminus and atropine subsequently put in the 

 eye produced mydriasis. 



14. Section of the trigeminus and the third nerve, and instillation 

 of atropine followed by mydriasis. 



15. In an ordinary atropine mydriasis direct electrical stimulation 

 of the sphincter produces myosis, but if the pupil be completely under 

 atropine stimulation of the sphincter has no effect. 



16. Czermak out away the cornea, letting out the contents of the 

 anterior chamber, and on adding atropine produced mydriasis. 



