Tissue of the Tongue in Inflammation, 393 



In my method of obseryation I followed in the main that employed by 

 Prof. Cohnheim. That method was, however, modified in the following 

 important particulars: — 1. The toad being preferred to the frog on the 

 grounds already stated, I found it necessary to employ very much larger 

 quantities of curare. The dose used by Cohnheim did not exceed O'OOl 

 grain, a quantity which is well known to be sufficient for the frog. But 

 in the toad I found that 0*004 grain was required, and that it was 

 necessary to repeat the injection every 36 or 48 hours during the course 

 of each observation. 2. The support on w^hich the body of the animal 



Outline sketch of the cork bupp(n-t used in ail the experiments (^actual -size). The 

 dotted lines represent the outline of the tongue and head. 



rested was not of glass, but of cork. On either side of it is a block 

 of cork, which answers the purpose of Cohnheim's cork border. The 

 small oblong plate of glass used by him is dispensed with. 3. In order 

 to prepare the tongue for observation, it is necessary first to distend 

 the lymph-sac by injecting into it -J-per-cent. solution of common 

 salt with the aid of a hypodermic syringe, and secondly to divide the 

 mucous membrane which constitutes its roof with fine scissors. This 

 having been accomplished, the cut edges are drawn aside so as to expose 

 the surface of the septum of muscular fibres which divides the lymph- 

 sac into two parts. A well-lighted field is thus obtained, in which the 

 most delicate details of structure can be satisfactorily observed, even 

 under high powers. 



The injury thus inflicted on the organ is so trifling that, provided that 

 care has been taken to guard against the production of haemorrhage, there 

 is at first no evidence of any pathological disturbance. Soon, however, 

 the changes (of which an account has been already given) begin to present 

 themselves, the several phenomena following each other in the order in 

 which they were originally described by Prof. Cohnheim. I would only 

 remark that the vascular changes can be studied very advantageously, 

 and in particular that the process of emigration displays itself before the 

 observer with wonderful beauty and distinctness. 



As in my observations I confined myself entirely to the behaviour of 

 the fixed elements of the tissue, I shall say nothing more of the vascular 



