312 Mr. J. J. Bowrey on the Physiological Action of [Apr. 11, 



of an emulsion to a fine healthy kitten weighing about 2 lbs. The 

 effect on the mouth and fauces was so immediate that but a small 

 fraction of the dose was swallowed, the instantaneous choking causing 

 the discharge of most of the emulsion, while the large quantity of 

 frothy saliva which directly began to flow must have washed the 

 mouth out completely. 



In two or three minutes the animal appeared to be trying to vomit, 

 but possibly it was merely choking up the thick saliva. 



9.26 a.m. Passed ordinary faeces. 



9.28 a.m. Vomited violently ; this repeated at 9.37 and 9.43. Up 

 to this time it kept on its legs, now and then moving about slowly ; it 

 appeared very disinclined to move, yet impelled to do so. 



9.45 a.m. Lay down and, except when vomiting or roused, remained 

 lying down as if sleeping till three o'clock. During the latter part of 

 the time, when disturbed, it would walk a few steps, but was in great 

 danger of falling over on its side. 



10.8 a.m. Convulsive vomiting of a thick greenish-yellow liquid, re- 

 peated at 10.33 ; 11.5 ; 11.50 a.m., and 12.20, and 1.20 p.m. Each time 

 the vomiting occurred after the kitten had been disturbed, or had 

 itself moved a few steps ; it screamed during each vomiting, and even 

 during an attempt to vomit. 



At 3 o'clock in the afternoon it walked out of the laboratory into 

 the office, and there went to sleep until removed to my lodgings ; it 

 slept all the evening and night, and was still sleepy next morning. 



All food and drink were refused on the day of administration ; next 

 morning it tried to eat a morsel of meat, but did not swallow any of 

 it ; later in the day it drank some milk ; after this it recovered 

 rapidly. 



The poison was given on an empty stomach. There were alto- 

 gether ten actual or attempted vomitings, nine of which occurred 

 within the first four and a half hours. Two hours after the adminis- 

 tration it seemed to be in a dying state, after this time it gradually 

 improved; very likely had it been disturbed when in its weakest con- 

 dition, convulsions would have come on, and death would have been 

 the result. 



Effect on a Kitten, given suhcutaneously . 

 Experiment VI. 



12.45 p.m. Injected -j? cub. centim. of solution of the crude poison in 

 40 per cent, spirit under the skin of neck of a kitten weighing 1 J lbs. 

 The \ cub. centim. of solution contained gr., i.e., 2*6 mgms. of the 

 poison. 



12.53 p.m. Vomited. 



12.56 Vomited violently. Unsteady on its legs ; afraid to 



