314 Mr. J, J. Bowrey on the Physiological Action of [Apr. 11, 



Experiment VIII. 



Tried to give a mouse \ mgm., i.e., nearly gr. pure hydrated 

 urechitoxin, dissolved in cub. centim. of spirit (30 per cent.), but part 

 was swallowed, certainly not more than ¥ ^ gr. In two hours the 

 animal was sluggish, clinging to the ground as if afraid of falling over 

 on its side. In six hours so paralysed as to be unable to govern its 

 movements, tumbling over if it tried to move from one spot to another, 

 its limbs trembling much, and its breathing difficult and convulsive. 

 Next morning, nineteen hours after the poison had been given, the 

 mouse was found dead and stiff. 



These mice were affected exactly as were those to which the crude 

 poison was administered. The effects, however, appeared much more 

 quickly, no doubt because the urechitoxin was given as a perfect 

 solution. 



Effects of small repeated doses of Urechitoxin {given by the Mouth) on 



Cats. 



Experiment IX. 



To a healthy kitten, weighing about 2 lbs., -g\ gr., i.e., nearly 1^ 

 mgms. of pure hydrated urechitoxin was given. The poison was dis- 

 solved in a drop of spirit which was allowed to fall into the back of 

 the kitten's mouth. Frothy saliva began to flow directly, the dis- 

 charge continuing for nearly forty minutes. I think some of the 

 poison must have been got rid of in the saliva. No other effect 

 followed. Next day the dose was repeated with the same effect ; after 

 the flow of saliva had ceased it ate, but about three hours after the 

 administration of the second dose the animal was seized with strong 

 convulsions, crying out spasmodically and gasping for breath. It 

 repeatedly passed urine, also a little faeces, and died in the convulsions. 



Experiment X. 



Administered -^-to E r -> ^- e "> ne &rly 0*26 mgms. pure hydrated urechi- 

 toxin to a kitten weighing about 2 lbs. The poison was given in one 

 drop of spirit (50 per cent.), and was allowed to fall into the throat of 

 the animal. The dose was repeated daily for the four succeeding days, 

 then a day missed ; after which the dose was given twice more. In 

 all, seven doses were administered in eight days ; during this time the 

 kitten was dull, and had but little appetite. It was found dead within 

 an hour of the exhibition of the last dose, and unfortunately was not 

 seen alive after the poison was given. The total quantity , of poison 

 given was ¥ V gr., rather less than 2 mgms. 



On opening the kitten a remarkable absence of fat was observed, the 

 tissues were pale, the lungs almost colourless, and the tongue very 

 white. The large arteries were empty, the large veins gorged with 



