1878.] the Poisonous Principle o/Urechites Suberecta. 315 



blood, the left ventricle quite empty, the right ventricle arid the 

 auricles were very full, in each auricle was a clot, that in the right 

 very fibrinous and apparently growing from its walls. The liver was 

 normal, the gall-bladder very full, the bile tinging the surrounding 

 tissues. The stomach distended with gas, otherwise empty, its walls 

 thick and stiff, the intestines down to the appendix thick and stiff, 

 indeed almost wiry, empty, and contracted, so as to have the appear- 

 ance of a solid cylinder more than that of a tube on being cut through 

 transversely. This condition was not observable below the appendix, 

 the lower part of the large intestines contained much feecal matter. 

 The bladder was empty, the kidneys apparently normal, their external 

 blood-vessels beautifully injected. The body was opened three and a 

 half hours after death. 



Experiment XI. 



In this experiment gr., i.e., 0*13 mgm. of pure hydrated 



urechitoxin, in one drop of spirit (40 per cent.), was administered to a 

 kitten on each of the dates noted below. 



February 3rd. — First dose given. No effect noticed. Appetite good. 

 Weight 2 lbs. 10 ozs. 



February 4th. — No effect. Appetite good. 



February 5th, 6th, 7th. — Saliva flowed for a short time ; vomited after 

 dose. - Appetite good. 



February 8th, 10th, 11th. — The administration of each dose was 

 followed by retching. Appetite good. Weight now 2 lbs. 8 ozs. 



February 12th and 13th. — No vomiting. 



February 14th, 15th, 17th. — Violent vomiting in a few minutes. 

 Appetite still fairly good. Weight from 2 lbs. 7 ozs. to 2 lbs. 9 ozs. 



February 18th and 19th. — Did not vomit nor care to eat. Weight 

 fell on the 19th to 2 lbs. 6 ozs. 



February 20th. — The last dose given. No vomiting. At first 

 refused to eat, but eight hours after receiving the poison it ate a little. 

 Weight 2 lbs. 5^ ozs. 



Next morning it was found dead ; it had evidently died in convul- 

 sions. 



Its dead weight was 2 lbs. 4 J ozs. The pupils of the eyes were so 

 enlarged as to reduce the irises to mere circular lines ; this appearance 

 I have noticed in every cat killed by urechitoxin. The kitten was in 

 good condition ; on opening it a large quantity of fat was found sur- 

 rounding the internal organs, otherwise the appearances were similar 

 to those noted in Experiment X. The weight was taken each day 

 before food was given to the animal, and the poison was administered 

 by allowing the drop of spirit containing it to fall into the throat of 

 the. kitten immediately after it had been weighed. It was then re- 

 turned to its cage, and food speedily supplied to it. 



VOL. XXVII. x 



