316 Mr. J. J. Bowrey on the Physiological' Action of [Apr. 11, 



Experiment XII. 



This was an experiment similar to Experiment XI, excepting that 

 but one half the quantity of hydrated urechitoxin was given daily, 

 viz., xoVo § T -' 0'065 mgm. The kitten weighed 2 lbs. 2 ozs. 



February 3rd. — First dose given, repeated on the 4th, 5th, 6th, 7th, 

 8th, 10th, 11th, 12th, 13th, 14th, without any visible effect. Weight 

 varying from 2 lbs. to 2 lbs. 2 ozs. Appetite good. 



February 15th, 17th, 18th, 19th, 20th.— The kitten during this time 

 was dull but still ate fairly. Its weight declined to 1 lb. 15 ozs., one 

 morning being 1 lb. 13 ozs. Though it ate, its appetite was fast 

 failing. 



February 21st. — No appetite. Yery dull. Weight 1 lb. 14^- ozs. 



February 22nd. — Refused food entirely. Weight 1 lb. 13 ozs. Died 

 in convulsions in the evening ; it had become very thin. It was not 

 opened. 



Exp. XI. — Each dose -g-^ gr. Given 16 in 18 days. Total weight 

 given gr. = 2*1 mgm. Death on 18th day. Weight on 1st day 

 2 lbs. 10 ozs., on 18th day 2 lbs. 5J ozs. 



Exp. XII. — Each dose 10 1 00 gr. Given 18 in 20 days. Total weight 

 given nearly gr. = 1*2 mgm. Death on the 20th day. Weight on 

 1st day 2 lbs. 2 ozs., on 20th day 1 lb. 13 ozs. 



Experiment XIII. 



In this experiment the poison was given in a manner more likely to 

 ensure the swallowing of each dose completely, and also at the same 

 time to prevent its action on the fauces. A solution of pure hydrated 

 urechitoxin was prepared containing gr. of the poison in each cub. 

 centim., strong spirit being used as the solvent. A number of bits of 

 filtering paper — each about f-inch square — were suspended on pins. 

 Each of these pieces of paper received cub. centim. of the spirit 

 solution delivered from an accurately graduated pipette ; when the 

 spirit had completely evaporated, and the squares were dry, they were 

 placed in a stoppered bottle. To give the dose, a square of paper was 

 cut into shreds and mixed with a little butter — the grease appeared 

 to prevent the cat perceiving the bitter taste of the poison — and placed 

 in a bit of meat, which was then given to the animal. The cat was 

 liberally fed once every day about 11 a.m., its weight being taken first, 

 and the poison given immediately before the day's food was put in its 

 cage. I may remark that plenty of exercise was allowed to all the 

 animals experimented on, the cats having the run of large premises 

 during the day, their cages being closed at night only. • 



Red cat weighing 5 lbs. 4 ozs. Received first dose July 3rd. 

 Repeated on July 5th, 6th, 7th, 8th, 9th and 10th, during which time 

 its weight was constant. 



