318 Mr. J. J. Bowrey on the Physiological Action of [Apr. 11, 



Death one day after last dose, which was given fourteen days after the 

 first one. 



Exp. XIV. Dose 1 J 00 gr, 65 given, total weight of poison given 

 .JL. g r . — 4-2 mgms. Weight of cat 6 lbs., rose to 6^ lbs. Death 

 nearly two days after last dose, which was given eleven weeks after 

 the first one. 



Exp. XV. Dose y~<to~o ^ r -' 22 given, total weight of poison exhibited 

 ^ gr., = 1-42 mgm. Weight of kitten If lbs, fell to If lbs. Death 

 two days after last dose, which was given twenty- six days after the 

 first one. 



Three other cats were experimented on in a similar manner, two of 

 them receiving about 100 squares each, and the other about 40 up to 

 the time when the experiments were discontinued. Except very 

 occasional vomiting these cats appeared in perfect health ; none of 

 them lost weight, while one gained considerably. Only a portion of 

 the squares of poisoned paper were taken from the same lot as those 

 used in Experiments XIII, XIV, and XV, most of them were from a 

 new batch prepared from a solution which had been kept for a long 

 time. I have found that weak solutions are apt in time to lose their 

 bitterness, indeed, the papers prepared from this old solution had but 

 a very slight bitter taste ; this test, however, was not applied until the 

 absence of effect on the cats led me to suspect that something was 

 wrong. In all probability, for the greater part of the time, these 

 three cats were receiving but a fraction of the dose intended. 



Effect of Urecliitoxin on a Dog, given by Mouth. 

 Experiment XVI. 



One gr, i.e., 65 mgms. of crystallized hydrated urechitoxin, was put 

 on a piece of meat, another piece laid over it and the two bits of meat 

 lightly tied together with a piece of cotton and given to a medium- 

 sized dog ; no effect followed for an hour, then the animal vomited four 

 times in quick succession, the meat containing the urechitoxin was 

 found in the vomit, the quantity of poison apparently undiminished, 

 one edge of the layer of poison, however, was free, i.e., uncovered by 

 meat, and must have been in contact with the juices of the stomach. 

 The dog was watched for an hour and a-half after the vomiting was 

 over, during which time it slept naturally, showing no ill effects what- 

 ever. It was then left for the night, with food and water at its side, 

 in the full expectation of finding it quite well in the morning ; how- 

 ever, it was discovered dead and cold, the food and drink untouched. 



The internal organs were found to be congested, all the cavities of 

 the heart contained much thick black blood, the auricles being gorged. 

 There were marks of irritation on the inner face of the stomach. 

 The brain was normal. 



