320 Mr. J. J. Bowrey on the Physiological Action of [Apr. 11, 



opened immediately after death, no irritability of the heart was 

 noticeable on pricking that organ ; this want of irritability was 

 observed on subsequent occasions." 



Experiment XIX. 



Injected gr. = 3*2 mgms. pure hydrated nrechitoxin, under the 

 skin of neck of a full grown cat. The poison was in solution in 

 spirit. 



10.35 a.m. Poison injected. 

 10.50 Faeces passed. 



10.53 ,, Vomited violently. 



10.54 „ Do. 



10.59 ,, Do. merely bringing up a little frothy liquid. 



11.2 „ Do. do. do. 



11.7 „ Do. do. do. 



11.12 ,, Vomited violently, merely bringing up a little frothy liquid ; 

 it now appeared sleepy. 



11.22 a.m. Again vomited frothy liquid, now very sleepy. 

 11.27 ,, Passed urine. 



11.30 ,, Vomited violently and immediately lay down again. 

 11.40 „ Momentary convulsions. 

 11.46 „ Do. * do. 



11.48 ,, Very violent convulsions accompanied with cries. During 

 the fit life became extinct, 1 hour and 13 minutes after the injection of 

 the poison. At 11.10 o'clock a mouse was put with the cat, which 

 noticed but did not attempt to catch it. 



In each of these experiments on the action of large doses, the first 

 effect was to cause the animal to vomit, which, in Experiment XVIII, 

 was very speedily followed by convulsions and death, but, in Experi- 

 ments XVII and XIX, the vomiting occurred repeatedly, urine and 

 fasces were passed, and there was a marked disinclination to muscular 

 exertion before the final convulsions came on and life became extinct. 



Effect on Gats of very small doses, subcutaneously injected. 

 Experiment XX. 



Injected gr., = 0*65 mgm., pure hydrated alpha echitoxin, dis- 

 solved in I cub. centim. (40 per cent.) spirit, under the skin of neck 

 of a small full grown cat, weighing lbs. Neither food nor drink 

 was taken by the cat after the injection. 



10.50 a.m. Poison injected, a little appeared to escape from the 

 wound on withdrawing the syringe. 



11.10 a.m. Uneasy, licking lips, vomited. 



11.20 „ Do. do. 



11.35 „ Do. do. 



11.50 „ Do. do. 



