1878.] the Poisonous Principle of Urechites Suberecta. 323 



Fourth day. — 7.0 a.m. Vomited twice, bringing up much white frothy 

 liquid. Afterwards tasted some milk — drank no appreciable quantity. 



10.30 A.M. Vomited a quantity of liquid, looking like dilute milk. 



11.30 Would have nothing to do with a mouse. Lay down 

 almost wherever it was placed, and even if it wanted to reach another 

 spot, it moved but a few steps, trembling and but half-raised on its 

 legs, in danger of falling over on its side. It would lie down without 

 reaching the desired place, never moving two feet at one time. 



Weight 5 lbs. 11 ozs. It gradually got worse, twitching of the ears, 

 and indeed whole head, now occurred on its being forced to make the 

 slightest movement. The pupils very contracted, and not sensitive to 

 light. I think, however, that if the cat's attention could have been 

 aroused they would have expanded and proved sensitive. 



2.0 p.m. The cat now unable to keep on its feet ; even when placed 

 upon them it sank on to the ground without any attempt to take up a 

 restful or easy position. Saliva flowing from its mouth. 



3.0 p.m. to 3.10 p.m. While being moved convulsions, accompanied 

 with cries, came on, followed by vomiting and a second attack of con- 

 vulsions, in which it died. 



Weight now 5 lbs. 10 ozs. The eyes presented the usual enlarged 

 pupils. The body was immediately opened. Stomach inflated, con- 

 tained a little yellow mucus. Intestines contracted. Colon contained 

 a little hard fasces. Bladder contained a few drops of urine. Liver 

 and kidneys appeared normal, the veins of latter beautifully injected. 

 Lungs pink with a tinge of yellow, became cream-coloured as they 

 cooled. Heart filled. Pericardium, right ventricle full ; on cutting 

 into it some thick dark blood flowed, but a mass of coagulated blood 

 remained in it ; left ventricle contained a little red blood, which did 

 not coagulate until it was exposed to the air. External vessels of 

 brain congested ; no blood-points were seen in its substance on cutting 

 into it. Death took place 77 hours after the first injection and 53 

 hours after the second. The total weight of poison injected was 

 gr., i.e., nearly 2 mgms., equivalent to one-and-a-half millionth part of 

 the weight of the cat. 



Experiment XXII. 



Injected gr. pure hydrated urechitoxin, dissolved in spirit, under 

 skin of neck of a cat weighing 4 lbs. 10J- ozs. The animal was last 

 fed 16 hours before the injection. 



10.50 a.m. Poison injected. After it was liberated the animal lay 

 down, and remained so till 



11.25 a.m. When it began to lick its lips, but the uneasiness passed 

 off, and only occasionally did it give a lick, still lying down. 



11.55 a.m. Got up uneasy, mewing, licking lips. 



12 o'clock. Vomited frothy liquid. 



