﻿1875.] 
  

  

  Action 
  of 
  the 
  Crotalus-poison 
  } 
  fyc. 
  

  

  269 
  

  

  circulation 
  have 
  the 
  power 
  in 
  some 
  cases 
  of 
  annihilating 
  almost 
  instanta- 
  

   neously 
  the 
  irritability 
  of 
  the 
  cord 
  and 
  medulla, 
  as 
  in 
  others 
  they 
  have 
  of 
  

   arresting 
  the 
  heart's 
  action. 
  

  

  Experiment 
  VIII. 
  

  

  June 
  17th. 
  — 
  Ten 
  drops 
  of 
  the 
  blood 
  of 
  the 
  rabbit 
  described 
  in 
  the 
  last 
  

   experiment, 
  poisoned 
  by 
  Crotalus-viras, 
  were 
  injected 
  into 
  a 
  guineapig's 
  

   thigh 
  at 
  3.40 
  p.m. 
  

  

  The 
  guineapig 
  was 
  not 
  apparently 
  affected 
  constitutionally 
  by 
  the 
  

   poisoned 
  blood. 
  It 
  was 
  alive 
  the 
  next 
  morning 
  ; 
  but 
  the 
  leg 
  was 
  swollen 
  

   and 
  discoloured. 
  It 
  ultimately 
  recovered. 
  

  

  Experiment 
  IX. 
  

  

  June 
  24t7i, 
  1874. 
  — 
  A 
  full-grown 
  cat 
  was 
  chloralized 
  at 
  1.20 
  r.M. 
  J 
  of 
  

   a 
  grain 
  of 
  Crotalus--poison, 
  diluted 
  with 
  1 
  cub. 
  centim. 
  of 
  water, 
  was 
  in- 
  

   jected 
  into 
  the 
  jugular 
  vein. 
  The 
  respirations 
  were 
  immediately 
  quickened. 
  

  

  1.21. 
  Twitching 
  of 
  muscles 
  generally. 
  

  

  1.22. 
  Efforts 
  to 
  vomit. 
  " 
  Forcible 
  extension 
  of 
  limbs. 
  

  

  1.24. 
  Hurried 
  respiration 
  and 
  retching. 
  Keflex 
  action 
  perfect. 
  

  

  1.30. 
  Muscular 
  twitching 
  and 
  tetanic 
  stretching 
  of 
  limbs. 
  Efforts 
  to 
  

   vomit 
  continue. 
  Micturition. 
  Eolls 
  over 
  on 
  the 
  ground. 
  

  

  1.34. 
  Ataxy. 
  Staggers 
  when 
  walking, 
  which 
  it 
  can 
  only 
  do 
  for 
  a 
  few 
  

   paces. 
  Peculiar 
  twitching 
  of 
  diaphragm 
  ; 
  not 
  sjmchronous 
  with 
  respira- 
  

   tory 
  movements. 
  Eolls 
  over 
  on 
  its 
  side. 
  

  

  2 
  p.m. 
  In 
  the 
  same 
  state. 
  

  

  2.8. 
  Injected 
  § 
  of 
  a 
  grain 
  more 
  of 
  the 
  poison 
  into 
  the 
  same 
  jugular 
  

   vein. 
  The 
  animal 
  immediately 
  got 
  up 
  and 
  walked, 
  comparatively 
  steadily, 
  

   for 
  several 
  paces, 
  as 
  though 
  it 
  had 
  been 
  stimulated, 
  and 
  then 
  rolled 
  over. 
  

  

  2.16. 
  Twitching 
  of 
  diaphragm 
  continues 
  at 
  the 
  rate 
  of 
  150 
  per 
  minute. 
  

  

  2.18. 
  Again 
  got 
  up 
  and 
  walked 
  for 
  a 
  few 
  paces 
  ; 
  but 
  it 
  is 
  gradually 
  

   becoming 
  more 
  paralyzed. 
  

  

  2.44. 
  Violent 
  tetanic 
  spasms 
  of 
  limbs. 
  Eeflex 
  action 
  diminished. 
  

  

  2.46. 
  Eeflex 
  action 
  gone 
  from 
  eyes. 
  Deep 
  sighing 
  respiration. 
  

  

  2.47. 
  Convulsions. 
  Death. 
  Body 
  opened 
  immediately. 
  Lungs 
  deeply 
  

   congested 
  and 
  much 
  ecchymosed. 
  Deep 
  red 
  gelatinous 
  effusion 
  all 
  

   about 
  the 
  roots 
  of 
  the 
  lungs. 
  Heart 
  contracting. 
  Electrodes 
  applied 
  to 
  

   phrenic 
  caused 
  vigorous 
  contraction 
  of 
  diaphragm. 
  

  

  2.50. 
  Heart 
  ceased 
  to 
  contract 
  3 
  minutes 
  after 
  respiration 
  had 
  ceased. 
  

  

  2.52. 
  Electrodes 
  in 
  cord 
  ; 
  do 
  not 
  cause 
  contraction 
  of 
  limbs. 
  

  

  2.54. 
  The 
  sciatic 
  nerve, 
  when 
  irritated, 
  conveys 
  impressions; 
  muscles 
  of 
  

   legs 
  contract. 
  Blood 
  from 
  the 
  heart 
  and 
  great 
  vessels 
  did 
  not 
  form 
  a 
  

   coagulum, 
  and 
  remained 
  permanently 
  fluid. 
  Eed 
  corpuscles 
  of 
  blood 
  

   were 
  much 
  crenated. 
  

  

  Death 
  in 
  this 
  case 
  appeared 
  to 
  be 
  caused 
  through 
  the 
  medulla. 
  

  

  