﻿270 
  Drs. 
  Brunton 
  and 
  Fayrer 
  on 
  the 
  Physiological 
  [Feb. 
  18, 
  

  

  Experiment 
  X. 
  

  

  June 
  15th, 
  1874. 
  — 
  Action 
  of 
  Crotalus-Tpoison 
  on 
  the 
  frog. 
  

   A 
  frog's 
  hind 
  leg 
  was 
  ligatured 
  excluding 
  the 
  sciatic 
  nerve. 
  

   A 
  solution 
  of 
  CVotaks-poison 
  was 
  injected 
  into 
  the 
  lymph-sac 
  at 
  12.32 
  

   p.m. 
  

  

  2.30. 
  Sluggish, 
  but 
  not 
  otherwise 
  affected. 
  

   3.15. 
  In 
  the 
  same 
  condition. 
  

  

  June 
  16th. 
  — 
  12.3, 
  noon. 
  Sluggish, 
  but 
  can 
  still 
  move. 
  

   June 
  17th. 
  — 
  Found 
  dead 
  this 
  morning 
  early 
  ; 
  pupils 
  contracted. 
  

   Electrodes 
  applied 
  ; 
  no 
  reaction 
  in 
  either 
  cord 
  or 
  nerves 
  on 
  either 
  side 
  

   to 
  the 
  strongest 
  current. 
  

  

  The 
  frog 
  may 
  have 
  been 
  dead 
  some 
  hours. 
  

  

  Experiment 
  XI. 
  

  

  June 
  loth'. 
  — 
  At 
  3 
  p.m. 
  same 
  day 
  a 
  solution 
  of 
  Crotalus-Yenom 
  was 
  

   injected 
  into 
  the 
  dorsal 
  lymph-sac 
  of 
  a 
  frog, 
  the 
  aorta 
  having 
  been 
  pre- 
  

   viously 
  ligatured, 
  so 
  as 
  to 
  prevent 
  the 
  poison 
  from 
  affecting 
  the 
  trunks 
  

   or 
  peripheral 
  extremities 
  of 
  the 
  sciatic 
  nerves. 
  

  

  3.40. 
  The 
  frog 
  seems 
  quite 
  unaffected. 
  

  

  June 
  16th. 
  — 
  12.30, 
  noon. 
  Frog 
  dead 
  ; 
  not 
  rigid 
  ; 
  mouth 
  open. 
  

  

  Irritation 
  of 
  cord 
  with 
  strongest 
  current 
  does 
  not 
  cause 
  contraction 
  of 
  

   legs. 
  Irritation 
  of 
  sciatic 
  with 
  coil 
  at 
  24 
  causes 
  twitchings 
  of 
  gastro- 
  

   cnemius. 
  

  

  Neither 
  of 
  these 
  two 
  experiments 
  give 
  any 
  definite 
  results, 
  as 
  the 
  

   period 
  intervening 
  between 
  death 
  and 
  examination 
  of 
  the 
  condition 
  of 
  the 
  

   nerve-centres 
  was 
  not 
  determined 
  exactly. 
  

  

  The 
  results 
  of 
  the 
  following 
  experiments 
  show 
  that 
  the 
  local 
  as 
  well 
  as 
  

   the 
  general 
  effect 
  of 
  the 
  cobra- 
  and 
  Crotcdus--poisons, 
  i. 
  e. 
  colubrine 
  and 
  

   viperine, 
  is 
  to 
  cause 
  hseinorrhage, 
  ecchymosis, 
  and 
  sanguinolent 
  effusions 
  

   into 
  the 
  areolar 
  tissue, 
  not 
  only 
  at 
  the 
  seat 
  of 
  inoculation 
  and 
  its 
  neigh- 
  

   bourhood, 
  but 
  also 
  in 
  the 
  mucous 
  membranes 
  and 
  other 
  vascular 
  parts. 
  

   It 
  is 
  obvious 
  also 
  that 
  the 
  Grotalus-^omon. 
  acts 
  more 
  energetically 
  in 
  * 
  

   this 
  respect 
  than 
  the 
  cobra-poison, 
  and 
  that 
  this 
  is 
  perhaps 
  one 
  of 
  the 
  

   most 
  marked 
  distinctions 
  between 
  them. 
  

  

  Experiment 
  XII. 
  

  

  August 
  6th, 
  1874. 
  — 
  A 
  cat 
  was 
  chloralized, 
  and 
  part 
  of 
  the 
  mesentery 
  

   placed 
  under 
  the 
  microscope 
  on 
  the 
  warm 
  stage. 
  Crotalus-ipoisoji, 
  dilu- 
  

   ted 
  with 
  water, 
  was 
  then 
  applied 
  to 
  the 
  mesentery, 
  and 
  its 
  effects 
  watched. 
  

   The 
  white 
  corpuscles 
  were 
  observed 
  to 
  cling 
  in 
  quantities 
  to 
  the 
  walls 
  of 
  

   the 
  vessels, 
  and 
  as 
  the 
  current 
  of 
  blood 
  hurried 
  through 
  them, 
  some 
  masses 
  

   of 
  pale 
  matter, 
  like 
  aggregation 
  of 
  white 
  corpuscles, 
  were 
  observed 
  to 
  pass 
  

   with 
  the 
  stream 
  ; 
  very 
  soon, 
  marked 
  extravasation 
  of 
  red 
  corpuscles 
  took 
  

  

  