﻿292 
  Messrs. 
  J. 
  G. 
  M'Kendrick 
  and 
  J. 
  Dewar 
  on 
  

  

  without 
  coiiyu1s':oiis. 
  The 
  temperature 
  of 
  the 
  body 
  fell 
  6° 
  to 
  8° 
  below 
  

   the 
  normal. 
  An 
  examination 
  of 
  the 
  body, 
  made 
  immediately 
  after 
  death, 
  

   showed 
  the 
  following 
  appearances 
  : 
  — 
  (1) 
  The 
  vessels 
  on 
  the 
  surface 
  of 
  

   the 
  brain 
  were 
  somewhat 
  congested 
  ; 
  the 
  substance 
  of 
  the 
  brain 
  itself 
  did 
  

   not 
  exhibit 
  any 
  increase 
  of 
  vascularity 
  ; 
  (2) 
  the 
  lungs 
  were 
  congested, 
  

   more 
  especially 
  along 
  the 
  borders 
  ; 
  (3) 
  the 
  heart 
  was 
  in 
  a 
  state 
  of 
  diastole 
  

   and 
  full 
  of 
  dark-coloured 
  blood 
  ; 
  (4) 
  the 
  veins 
  in 
  the 
  mesentery 
  and 
  the 
  

   larger 
  vessels 
  on 
  the 
  intestine 
  were 
  much 
  congested 
  ; 
  (5) 
  the 
  liver 
  showed 
  

   numerous 
  minute 
  ring-like 
  congestions, 
  indicating 
  congestion 
  of 
  the 
  portal 
  

   system 
  ; 
  (6) 
  the 
  kidneys 
  and 
  other 
  abdominal 
  and 
  pelvic 
  viscera 
  were 
  

   normal 
  in 
  appearance 
  ; 
  and 
  (7) 
  the 
  urine 
  in 
  the 
  bladder 
  contained 
  no 
  

   albumen 
  or 
  sugar. 
  

  

  From 
  these 
  symptoms 
  and 
  post 
  mortem 
  appearances, 
  and 
  from 
  special 
  

   methods 
  of 
  experiment, 
  we 
  draw 
  the 
  following 
  conclusions 
  regarding 
  the 
  

   action 
  of 
  hydrochlorate 
  of 
  chinoline. 
  

  

  1. 
  Action 
  on 
  the 
  Nervous 
  System. 
  — 
  The 
  action 
  is 
  chiefly, 
  if 
  not 
  altoge- 
  

   ther, 
  on 
  the 
  nerve-centres, 
  and 
  not 
  on 
  the 
  nerves 
  or 
  on 
  their 
  peripheral 
  

   terminations. 
  When 
  the 
  sciatic 
  nerve 
  is 
  irritated 
  by 
  very 
  feeble 
  Faradic 
  

   currents, 
  it 
  manifests 
  no 
  diminution 
  of 
  sensibility, 
  and 
  the 
  muscles 
  sup- 
  

   plied 
  by 
  the 
  nerve 
  contract 
  with 
  apparently 
  their 
  normal 
  energy. 
  The 
  

   nerves 
  of 
  a 
  frog 
  killed 
  by 
  hydrochlorate 
  of 
  chinoline 
  show 
  all 
  the 
  pro- 
  

   perties 
  of 
  nerves 
  obtained 
  from 
  a 
  non-poisoned 
  animal. 
  The 
  sympathetic 
  

   system 
  of 
  nerves 
  is 
  not 
  usually 
  affected 
  to 
  any 
  appreciable 
  extent, 
  as 
  evi- 
  

   denced 
  by 
  the 
  normal 
  condition 
  of 
  the 
  pupil, 
  the 
  absence 
  of 
  dilatation 
  of 
  

   the 
  vessels 
  in 
  the 
  ear 
  (consequent 
  on 
  paralysis 
  of 
  the 
  vaso-motor 
  system), 
  

   and 
  by 
  the 
  fact 
  that, 
  in 
  an 
  animal 
  deeply 
  under 
  the 
  influence 
  of 
  chinoline, 
  

   the 
  phenomena 
  following 
  section 
  and 
  irritation 
  of 
  the 
  sympathetic 
  in 
  the 
  

   neck 
  of 
  a 
  rabbit 
  take 
  place 
  to 
  the 
  same 
  extent 
  and 
  in 
  the 
  same 
  order 
  as 
  

   in 
  a 
  non-poisoned 
  animal. 
  In 
  several 
  instances 
  we 
  have 
  observed 
  dila- 
  

   tation 
  of 
  the 
  vessels 
  of 
  the 
  ear 
  and 
  slight 
  contraction 
  of 
  the 
  pupil 
  ; 
  but 
  

   these, 
  from 
  their 
  rare 
  occurrence, 
  appear 
  to 
  be 
  exceptional. 
  No 
  change 
  

   was 
  observed 
  in 
  the 
  action 
  of 
  the 
  pneumogastric 
  nerve, 
  so 
  far 
  as 
  could 
  

   be 
  ascertained 
  by 
  the 
  effect 
  on 
  the 
  heart 
  produced 
  by 
  Faradic 
  irritation 
  

   of 
  that 
  nerve. 
  We 
  have 
  observed 
  no 
  symptoms 
  leading 
  us 
  to 
  suspect 
  

   irritation, 
  or 
  paralysis, 
  of 
  the 
  centres 
  in 
  the 
  cerebellum, 
  or 
  in 
  the 
  ganglia 
  

   at 
  the 
  base 
  of 
  the 
  brain 
  ; 
  but 
  in 
  lethal 
  doses 
  the 
  respiratory 
  centres 
  in 
  

   the 
  medulla 
  oblongata 
  become 
  gradually 
  affected, 
  as 
  shown 
  by 
  the 
  dimi- 
  

   nution 
  of 
  the 
  respiratory 
  movements 
  both 
  in 
  force 
  and 
  frequency. 
  The 
  

   motor 
  columns 
  of 
  the 
  spinal 
  cord 
  do 
  not 
  lose 
  their 
  power 
  of 
  conduction 
  

   from 
  the 
  encephalon 
  to 
  various 
  parts 
  of 
  the 
  body, 
  because, 
  on 
  irritating 
  

   with 
  a 
  weak 
  Faradic 
  current 
  the 
  end 
  of 
  the 
  cord 
  in 
  a 
  rabbit 
  decapitated 
  

   while 
  deeply 
  under 
  the 
  influence 
  of 
  the 
  substance, 
  powerful 
  convulsive 
  

   movements 
  ensued. 
  The 
  reflex 
  activity 
  of 
  the 
  cord 
  is 
  much 
  weakened, 
  

   inasmuch 
  as 
  it 
  cannot 
  be 
  excited 
  by 
  pinching 
  or 
  pricking 
  ; 
  but 
  it 
  is 
  not 
  

   entirely 
  lost, 
  because 
  it 
  may 
  be 
  excited 
  by 
  Faradic 
  stimulation; 
  and 
  it 
  has 
  

  

  