﻿29^ 
  Messrs. 
  J. 
  G. 
  M'Kendrick 
  and 
  J. 
  Dewar 
  on 
  

  

  after 
  a 
  state 
  of 
  stupor 
  had 
  been 
  produced, 
  the 
  animal 
  was 
  less 
  likely 
  to 
  

   recover, 
  while 
  it 
  was 
  observed 
  that, 
  frequently, 
  before 
  death, 
  there 
  were 
  

   jactations 
  of 
  one 
  or 
  other 
  of 
  the 
  limbs 
  and 
  convulsive 
  twitchings 
  about 
  

   the 
  mouth. 
  

  

  2. 
  Bases 
  obtained 
  by 
  distillation 
  between 
  280° 
  and 
  300° 
  C. 
  

   Dispoline 
  <$*c, 
  C 
  n 
  H 
  n 
  If. 
  

  

  It 
  was 
  now 
  observed 
  that 
  the 
  symptoms 
  following 
  subcutaneous 
  injec- 
  

   tion 
  were 
  considerably 
  different 
  from 
  those 
  of 
  chinoline. 
  One 
  grain 
  for 
  

   each 
  pound 
  weight 
  of 
  the 
  rabbit 
  produced, 
  in" 
  about 
  five 
  minutes, 
  apparent 
  

   uneasiness, 
  side 
  to 
  side 
  movements 
  of 
  the 
  head, 
  with 
  a 
  tendency 
  occa- 
  

   sionally 
  to 
  move 
  backwards. 
  This 
  condition 
  continued 
  for 
  three 
  or 
  four 
  

   minutes, 
  when 
  the 
  animal 
  lay 
  fiat 
  on 
  its 
  abdomen 
  with 
  its 
  legs 
  out- 
  

   spread. 
  It 
  was 
  not 
  in 
  a 
  state 
  of 
  complete 
  unconsciousness. 
  There 
  was 
  

   no 
  anaesthesia. 
  In 
  several 
  instances 
  there 
  were 
  compulsive 
  twitchings 
  

   of 
  the 
  limbs, 
  grinding 
  of 
  the 
  teeth, 
  and 
  a 
  slight 
  tendency 
  to 
  opisthotonos. 
  

   The 
  lethal 
  dose 
  was 
  smaller 
  than 
  in 
  the 
  case 
  of 
  chinoline. 
  The 
  effects 
  

   were 
  a 
  longer 
  time 
  in 
  appearing, 
  and 
  they 
  had 
  more 
  of 
  a 
  spinal 
  than 
  of 
  

   a 
  cerebral 
  character. 
  

  

  3. 
  Bases 
  obtained 
  by 
  distillation 
  above 
  300° 
  C. 
  

   TetraHroline 
  Sfc, 
  C 
  12 
  H 
  ]3 
  X. 
  

  

  These 
  were 
  found 
  to 
  be 
  still 
  more 
  active. 
  A 
  dose 
  of 
  J 
  of 
  a 
  grain 
  

   per 
  pound 
  weight 
  produced, 
  in 
  eight 
  or 
  ten 
  minutes 
  after 
  it 
  had 
  been 
  

   subcutaneously 
  injected, 
  violent 
  convulsions, 
  and 
  was 
  almost 
  invariably 
  

   fatal. 
  During 
  the 
  first 
  five 
  minutes 
  after 
  the 
  introduction 
  of 
  the 
  poison, 
  

   no 
  marked 
  symptoms 
  were 
  noticed. 
  At 
  the 
  end 
  of 
  this 
  time, 
  the 
  animal 
  

   became 
  uneasy, 
  ran 
  forwards 
  in 
  an 
  excited 
  manner, 
  and 
  then 
  fell 
  over 
  on 
  

   its 
  side. 
  The 
  convulsions 
  which 
  ensued 
  were 
  similar 
  to 
  those 
  produced 
  

   by 
  the 
  action 
  of 
  large 
  doses 
  of 
  quinine 
  or 
  cinchonine. 
  They 
  did 
  not 
  

   resemble 
  the 
  tetanic 
  spasms 
  produced 
  by 
  strychnia, 
  as 
  they 
  were 
  not 
  

   excited 
  b} 
  r 
  peripheral 
  irritations 
  ; 
  but 
  they 
  had 
  an 
  epileptiform 
  character, 
  

   consisting 
  of 
  irregular 
  jactations 
  of 
  the 
  limbs, 
  cranching 
  of 
  the 
  teeth, 
  

   movements 
  of 
  the 
  eyeballs, 
  pawing 
  movements 
  of 
  the 
  fore 
  limbs, 
  &c. 
  

   The 
  animal 
  seemed 
  to 
  be 
  semiconscious 
  throughout. 
  It 
  was 
  still 
  sus- 
  

   ceptible 
  to 
  pain. 
  

  

  A 
  consideration 
  of 
  the 
  effects 
  just 
  described 
  indicates 
  that, 
  as 
  we 
  

   ascend 
  from 
  the 
  lower 
  to 
  the 
  higher 
  members 
  of 
  the 
  chinoline 
  series 
  of 
  

   bases, 
  the 
  physiological 
  action 
  becomes 
  modified 
  as 
  follows 
  : 
  — 
  

  

  1. 
  The 
  action 
  on 
  the 
  sensory 
  centres 
  of 
  the 
  encephalon 
  becomes 
  less 
  

   marked, 
  until 
  in 
  the 
  highest 
  group 
  there 
  is 
  no 
  unconsciousness, 
  but 
  only 
  

   slight 
  stupor. 
  

  

  2. 
  The 
  actions 
  of 
  the 
  motor 
  centres 
  of 
  the 
  encephalon 
  and 
  spinal 
  cord 
  

   are 
  not 
  affected 
  in 
  the 
  lowest 
  group, 
  but 
  become 
  gradually 
  more 
  and 
  

  

  