﻿542 
  Dr. 
  F. 
  W. 
  Pavy 
  on 
  the 
  Production 
  of 
  Glycosuria. 
  [June 
  17, 
  

  

  negative 
  result 
  would 
  be 
  obtained. 
  I 
  took 
  care, 
  by 
  slowuess 
  of 
  injection, 
  

   to 
  avoid 
  allowing 
  the 
  circulation 
  through 
  the 
  liver 
  to 
  be 
  influenced 
  by 
  

   the 
  effect 
  of 
  increased 
  pressure 
  within 
  the 
  portal 
  system. 
  I 
  am 
  not 
  

   aware, 
  aud 
  do 
  uo 
  thiuk 
  from 
  my 
  previous 
  experience, 
  that 
  any 
  fallacy 
  

   would 
  be 
  likely 
  to 
  arise 
  from 
  such 
  a 
  source 
  ; 
  but 
  I 
  nevertheless 
  deemed 
  

   it 
  advisable 
  to 
  exclude 
  the 
  possibility 
  of 
  its 
  occurrence. 
  

  

  Having 
  noticed 
  the 
  effect 
  which 
  has 
  been 
  described 
  from 
  the 
  injec- 
  

   tion 
  of 
  oxygenated 
  blood 
  into 
  the 
  portal 
  system, 
  it 
  became 
  necessary 
  to 
  

   ascertain 
  positively 
  that 
  it 
  was 
  attributable 
  to 
  the 
  oxygenated 
  condition 
  

   of 
  the 
  blood, 
  and 
  not 
  to 
  any 
  other 
  cause. 
  To 
  decide 
  this 
  point 
  an 
  ap- 
  

   peal 
  to 
  the 
  counterpart 
  experiment 
  was 
  made. 
  Defibrinated 
  venous 
  

   instead 
  of 
  arterial 
  blood 
  was 
  injected 
  into 
  a 
  branch 
  of 
  the 
  mesenteric 
  

   vein 
  ; 
  and 
  upon 
  each 
  occasion 
  where 
  such 
  an 
  operation 
  has 
  been 
  per- 
  

   formed 
  a 
  negative 
  result 
  has 
  been 
  obtained. 
  With 
  the 
  evidence 
  thus 
  

   furnished 
  the 
  conclusion 
  may 
  be 
  warrantable 
  drawn, 
  that 
  oxygenated 
  

   blood 
  in 
  some 
  manner 
  influences 
  the 
  liver, 
  so 
  as 
  to 
  lead 
  to 
  the 
  production 
  

   of 
  glycosuria. 
  It 
  may 
  be 
  inferred 
  that, 
  contrary 
  to 
  the 
  effect 
  of 
  venous 
  

   blood 
  under 
  a 
  natural 
  state 
  of 
  the 
  circulation, 
  it 
  promotes 
  the 
  transforma- 
  

   tion 
  of 
  amyloid 
  substance 
  into 
  sugar. 
  

  

  In 
  performing 
  these 
  experiments 
  of 
  injecting 
  defibrinated 
  blood 
  into 
  

   the 
  portal 
  system, 
  I 
  came 
  across 
  an 
  effect 
  which 
  I 
  had 
  not 
  anticipated, 
  

   and 
  which 
  upon 
  several 
  occasions 
  frustrated 
  the 
  object 
  I 
  had 
  in 
  view. 
  

   Defibrinated 
  blood, 
  as 
  experimental 
  physiologists 
  know, 
  may 
  be 
  injected 
  

   into 
  the 
  veins 
  of 
  the 
  general 
  system 
  without 
  producing 
  any 
  special 
  effect. 
  

   Injected, 
  however, 
  into 
  the 
  portal 
  system, 
  it 
  frequently 
  gave 
  rise 
  to 
  a 
  

   complete 
  stoppage 
  of 
  the 
  portal 
  circulation 
  by 
  inducing 
  coagulation 
  of 
  the 
  

   blood 
  in 
  the 
  trunk 
  of 
  the 
  portal 
  vein 
  and 
  its 
  ramifications 
  in 
  the 
  liver. 
  

   I 
  merely 
  mention 
  the 
  fact 
  in 
  this 
  place, 
  and 
  am 
  not 
  aware 
  that 
  it 
  has 
  

   hitherto 
  been 
  noticed 
  ; 
  but 
  it 
  may 
  hereafter 
  be 
  found 
  of 
  interest 
  in 
  con- 
  

   nexion 
  with 
  the 
  subject 
  of 
  the 
  coagulation 
  of 
  blood. 
  Finding 
  that 
  

   several 
  of 
  my 
  experiments 
  proved 
  fruitless 
  from 
  this 
  cause, 
  I 
  tried 
  means 
  

   to 
  obviate 
  coagulation 
  occurring, 
  and 
  amongst 
  these 
  was 
  extirpation 
  of 
  

   the 
  spleen. 
  With 
  this 
  operation, 
  as 
  far 
  as 
  my 
  experience 
  has 
  yet 
  gone, 
  

   the 
  coagulatiou 
  is 
  prevented 
  ; 
  and, 
  moreover, 
  I 
  have 
  noticed 
  that 
  the 
  blood 
  

   in 
  the 
  general 
  system 
  after 
  death 
  fails 
  to 
  possess 
  its 
  ordinary 
  coagulating 
  

   property. 
  

  

  The 
  suggestion 
  naturally 
  occurs, 
  that 
  what 
  has 
  been 
  stated 
  in 
  this 
  

   communication 
  affords 
  an 
  explanation 
  of 
  the 
  glycosuria 
  occurring 
  after 
  

   Bernard's 
  puncture 
  of 
  the 
  fourth 
  ventricle 
  and 
  the 
  various 
  lesions 
  of 
  the 
  

   sympathetic. 
  Without 
  any 
  new 
  agent 
  being 
  called 
  in, 
  sufficient 
  is 
  pre- 
  

   sented 
  in 
  the 
  state 
  of 
  the 
  blood 
  to 
  account 
  for 
  the 
  production 
  of 
  sugar 
  

   that 
  occurs. 
  By 
  a 
  vaso-motor 
  paralysis 
  affecting 
  the 
  vessels 
  of 
  the 
  ehylo- 
  

   poietic 
  viscera 
  the 
  blood 
  will 
  reach 
  the 
  portal 
  system 
  without 
  having 
  become 
  

   dearterialized 
  in 
  its 
  natural 
  way 
  ; 
  and 
  in 
  this 
  state 
  it 
  has 
  been 
  shown 
  

   to 
  possess 
  the 
  property 
  of 
  acting 
  within 
  the 
  liver 
  in 
  such 
  a 
  manner 
  as 
  to 
  

   determine 
  the 
  production 
  of 
  glycosuria, 
  

  

  