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  On 
  the 
  Action 
  of 
  the 
  Chinoline 
  and 
  Pyridine 
  Bases. 
  

  

  active 
  physiologically, 
  but 
  the 
  action 
  differs 
  in 
  kind 
  from 
  that 
  of 
  the 
  

   simple 
  bases, 
  and 
  resembles 
  the 
  action 
  of 
  natural 
  bases 
  or 
  alkaloids 
  

   having 
  an 
  approximately 
  similar 
  chemical 
  composition. 
  

  

  7. 
  All 
  the 
  substances 
  examined 
  in 
  this 
  research 
  are 
  remarkable 
  for 
  not 
  

   possessing 
  any 
  specific 
  paralytic 
  action 
  on 
  the 
  heart 
  likely 
  to 
  cause 
  

   syncope 
  ; 
  but 
  they 
  destroy 
  life, 
  in 
  lethal 
  doses, 
  either 
  by 
  exhaustive 
  con- 
  

   vulsions 
  or 
  by 
  gradual 
  paralysis 
  of 
  the 
  centres 
  of 
  respiration, 
  thus 
  caus- 
  

   ing 
  asphyxia. 
  

  

  8. 
  There 
  is 
  no 
  immediate 
  action 
  on 
  the 
  sympathetic 
  system 
  of 
  nerves, 
  

   although 
  there 
  is 
  probably 
  a 
  secondary 
  action, 
  because 
  after 
  large 
  doses 
  

   the 
  vaso-motor 
  centre, 
  in 
  common 
  with 
  other 
  centres, 
  becomes 
  involved. 
  

  

  9. 
  There 
  is 
  no 
  appreciable 
  difference 
  between 
  the 
  physiological 
  action 
  

   of 
  the 
  bases 
  obtained 
  from 
  cinchona 
  and 
  those 
  derived 
  from 
  tar. 
  

  

  The 
  physiological 
  action 
  of 
  the 
  substitution 
  derivatives 
  of 
  these 
  sub- 
  

   stances 
  will 
  be 
  related 
  in 
  a 
  further 
  communication. 
  

  

  