84 



Messrs. Parkes and Wollowicz on the 



[Recess, 



insignificant, as to prove that 10 and 20 fluid ounces of claret, taken for 

 two periods of five days, caused no alteration in the elimination of nitro- 

 gen, when the egress of nitrogen was constant. 



Thus to express the result in grains, the daily nitrogen calculated from 

 the urea was, in the first period of ten days, 257*37 grains, and in the 

 second or wine-period 260 grains. In nine days of the two periods, the 

 daily nitrogen by soda-lime was 255*19 grains in the water-, and 253*35 

 grains in the wine-period. 



Nitrogen after claret. 



Days. 



21st day . 

 22nd day 

 23rd day. 

 24th day. 

 25th day. 

 26th day. 

 27th day. 

 28th day. 

 29th day. 

 30th day. 



Means . 



Urea. 



grammes. 

 45-500 

 42900 

 38-112 

 36-960 



"42-900" 

 41-128 

 44-646 

 38-739 

 27-777 



39-851 



Nitrogen 

 calculated from 



urea. 



grammes. 

 21-233 



20- 020 

 17-780 

 17-448 



'26026 



21- 193 

 20-805 

 18 078 

 12-938 



18-883 



Nitrogen 



by 



soda-lime. 



grammes. 

 20-779 



18-159 

 17-640 

 14-119 



20-110 

 18-548 

 13-324 



17-525 



As one determination of urea and three determinations of nitrogen by 

 soda-lime were lost, in order to find the daily amount of nitrogen in the 

 whole of the ten days, the soda-lime nitrogen of the 25th day may be 

 added to the total ureal nitrogen, and the mean taken. If this be done, 

 the mean daily excretion of nitrogen was 18*362 grammes. This gives 

 an excess of no less than 1*682 gramme over the first period, and 1*504 

 over the wine-period. The excess was so large, and was so unlike any- 

 thing seen before during any of the experiments, as to prove it was not 

 accidental. 



The question now arises, if the increase was owing to the direct effect 

 sf the wine. This seems unlikely, partly because some evidence of in- 

 crease would then have been obtained from the ten days during which 

 the wine was taken, and partly from another reason. During this last 

 period the man became ill; he was not feverish, but his pulse was quick. 

 On the 25th, 26th, and 2/th days there was some looseness of the bowels 

 and headache ; he could scarcely eat his food, and lost weight for the first 

 time. 



On the 29th day he was better, and on the 30th felt quite well, and on 

 that day the nitrogen (as determined in both ways) fell greatly. He 

 ascribed his illness to the monotony of his life, the sameness of his diet, 

 and the comparative want of exercise, whilst it is also possible that the 



