1871.] History of the Opium Alkaloids. 373 



Calculated. Found. 



C^~~ 216 4876 49-40 ^ 



H 21 21 4-74 5-01 



Br 2 160 36-12 .... 35-08 



N 14 3-16 



2 32 7-22 



C 18 H 20 BrNO 2 HBr 443 lOO'OO 



The slight excess of carbon and deficiency in bromine thus found are 

 doubtless due to the presence of a little deoxycodeia, the hydrobromate of 

 which requires 59'34 per cent, carbon and 21-98 per cent. Br. Another 

 specimen of bromocodide hydrobromate, prepared as above from the pro- 

 duct of three hours' digestion at 100° of one part codeia and three parts 

 48 per cent. HBr, yielded numbers indicating 51*6 per cent, carbon, 5*3 

 and 33*4 per cent. Br ; whilst a repetition of the purification process 

 scarcely altered the numbers. Owing to the great difficulty in preparing 

 the pure salt in quantity, no attempt to isolate and analyze the base itself 

 was made, the more so that the precipitate thrown down by carbo- 

 nate of soda from the pure hydrobromate appeared to tally in every respect 

 with the chlorocodide formerly examined ; their qualitative reactions, too, 

 are identical. 



The crude bromocodide hydrobromate obtained after five or six hours' 

 digestion of codeia with from three to five times its weight of 48 per cent. 

 HBr deposited, on standing for some days, crystals not readily soluble in cold 

 water ; recrystallized several times from boiling water, minute snow-white 

 crystals were ultimately obtained ; these slightly darkened on drying 

 over S0 4 H 2 , and more so at 100° and gave the following numbers on ana- 

 lysis : — 



0-3565 grm. gave 0-7760 C0 2 and 0-1960 H 2 0. 



0-3245 grm. gave 0*7045 C0 2 and 0*1790 H 2 ~0. 



0*2200 grm. burnt with' soda-lime gave 0-0570 Pt. 



0-1380 grm. boiled with N0 3 Hand Ag N0 3 gave 0*0700 AgBr. 



These numbers agree with those calculated for deoxycodeia hydrobro- 

 mate, as the following comparison shows : — 



Calculated. Found. 



C 18 216 59-34 59 36 59*21 



H 22 22 6-05 6-11 6-13 



N 14 3-84 3-69 



O : 32 8-79 



Br 80 21-98 21-59 



C J8 H 21 N0 2 HBr 364 100 00 



