376 



On the History of the Opium Alkaloids, [Mar. 9, 



analogous to that of bromotetracodeia ; it may therefore be termed chlo- 

 rotetracodeia. 



Specimen A.— 0-3880 grm. gave 0*1970 AgCl. 



0-3645 grm. gave 0-8395 C0 2 and 0*2120 H 2 0. 

 0-3940 grm. burnt with soda-lime gave 0*1080 Pt. 



Specimen B. — 0-4460 grm. gave 1-0150 C0 2 and 0*2560 H 6 0. 

 0-2350 grm. gave 1 250 AgCl. 



Found 



Calculated. , * s 



^ * N Specimen A. Specimen E. 



C 70 864 62-77 6281 .... 62 07 



H 97 87 6-32 6-46 6-38 



N 4 56 4-07 .... 3-90 



O l2 192 13-94 



Cl 5 177-5 12-90 12-56 1316 



C 72 H 83 C1N 4 12 , 4HC1 1376-5 100 00 



Specimen A had been three times precipitated by HC1 in large excess, 

 while specimen B had only been thrown down twice, and probably retained 

 a trace of bromotetracodeia. 



Specimen A converted into platinum-salt gave the following numbers 

 after drying at 100°. 



0-4215 grm. gave 0-0810 Pt= 19*22 per cent. 



The formula C 72 H 83 C1N 4 12 , 4 HC1, 2PtCl 4 requires 19-18 per cent. 



Like bromotetracodeia, the free base appears to absorb oxygen with 

 avidity. Dried as rapidly as possible at 100°, the precipitate thrown down 

 by carbonate of soda gave these numbers : — 



0*3880 grm. gave 0*9190 C0 2 and 0'2230 H o 0. 



0-3100 „ 0-0330 AgCl. 



Calculated. Found. 











c 72 



864 



64-74 



64*59 





83 



6-22 



6*38 



N 4 



56 



4-20 





Ox* 



296 



2218 





CI 



35-5 



2*66 



.... 2*64 



C 72 H 83 C1N 4 12 +0 6| 1334*5 100*00 



In all its physical and chemical properties chlorotetracodeia closely re- 

 sembles bromotetracodeia : their qualitative reactions are identical ; they 

 have an intense bitter taste and apparently but slight physiological action, 

 at any rate in small doses. 



My thanks are due to Mr. J. L. Bell, in whose laboratory the above ex- 

 periments were carried out. 



