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THE AMEBIC AN NATURALIST [Vol. XL VII 



matings, while in the other the control animals gave 56 

 surviving young from 35 matings. 



The fourth line summarizes the results of the matings 

 made with treated individuals. A total of 103 matings 

 have run the full term ; 43, or almost 42 per cent, of these, 

 have given negative results or early abortions ; while 35 

 control matings failed in only two cases to yield a full 

 term litter. Fourteen, or 131 per cent., of the matings 

 gave stillborn litters consisting of 30 individuals. Only one 

 stillborn litter occurred in the 35 control matings ; this was 

 a large litter of 4 young and the mother seemed almost 

 unable to carry them. The 103 matings of treated ani- 

 mals gave only 46 living litters, about 45 per cent., while 

 32 living litters, or 9H per cent., were produced by the 

 35 control matings. The 46 living litters from the alco- 

 holic individuals contained 89 young, 37 of which died 

 shortly after birth and 52 survived. The 32 living litters 

 from the normal animals consisted of 60 individuals, only 

 4 of which died while 56, or 93 per cent., of these survived. 



Of 119 full term young, 30 of which were stillborn, pro- 

 duced by the alcoholic animals, only 52, or less than 44 

 per cent., survived as against the 56, or 87^ per cent., 

 survivors among the (54 full-term control offspring. 



The bottom line of the table shows that 4 normally 

 mated females treated with alcohol during the period of 

 gestation gave 4 living litters, consisting each of 2 young. 

 One out of the 8 young died soon after birth. These 

 few cases would seem to indicate that the treatment, 

 when started at the beginning of gestation, was not par- 

 ticularly injurious to the embryos developing in utero. 



Are the Effects on the Offspring Transmitted? 



The offspring derived from the alcoholic individuals 

 are termed second generation animals, and were not 

 treated with alcohol. The sixth, seventh and eighth lines 

 of the table represent the data obtained from the few 

 full time matings that have been made with these guinea- 

 pigs. 



