No. 563] EFFECT OF INTOXICATING MALE PARENT 661 



In three cases second generation animals have been 

 mated with normal individuals and have produced per- 

 fect results, though the litters have been small. Three 

 litters are recorded containing a total of 4 young, all of 

 which survived. It might seem as though the normal 

 mate counteracted any defect which may have been pres- 

 ent in the second generation animals. 



The mating of second generation individuals with alco- 

 holized guinea-pigs gave decidedly different results. The 

 seventh line shows that 2 out of 3 such matings produced 

 stillborn young. In one of these cases the female was of 

 the second generation and the male alcoholic, and in the 

 other case the reverse condition existed; yet both com- 

 binations gave dead offspring, one litter of two and one 

 of three individuals. One of these specimens from the 

 second generation female by the alcoholic male was 

 grossly deformed. The third mating gave two surviving 

 young. At present there are too few matings of this 

 combination from which to draw conclusions, yet the 

 results obtained are the most disastrous of all. 



Nineteen matings between second generation animals 

 have been made. The outcome in these cases compares 

 very unfavorably with that from the control matings r 

 while the data are much of the same type as those ob- 

 tained from the alcoholic combinations. Seven, or almost 

 37 per cent., of the matings gave negative results. 

 Twelve living litters were born consisting of 19 individ- 

 uals, 6, or about 32 per cent., of which died very soon 

 after birth and showed various nervous disorders. One 

 was entirely eyeless and decidedly deformed. 



From the number of records available one might con- 

 clude that the effects of the alcoholic treatment were as 

 pronounced upon the offspring of the second generation 

 animals, although they had not been directly treated, as 

 they were upon the offspring of alcoholized individuals. 

 The poison acts upon the cells and tissues of the body, 

 the germ cells as well as other cells, and an offspring 

 derived from the weakened or affected germ cell has all 



