No. 563] EFFECT OF INTOXICATING MALE PARENT 663 



the cells of its body, both soma and germ, defective since 

 each of the cells is a descendant of the injured germ cell 

 combination. 



These are the initial experiments with mammals to 

 show that an injur}) of the, germ cells may express its 

 effects on the offspring and he passed through subsequent 

 generations. 



The actual outcome of the experiments may be more 

 fully recognized by a consideration of one of the most 

 striking cases. A large normal female, weighing about 

 700 grams, had given two normal young by a control 

 mating and had since given non-viable young by a mating 

 with an alcoholic male. She was then mated with another 

 large strong alcoholic male which weighed 740 grams and 

 which had given before this mating apparently healthy 

 offspring by normal females. The mating resulted in the 

 production of 4 young, all small and rather excitable in 

 their behavior. These individuals from the normal 

 mother and the alcoholized father grew slowly, although 

 they ate freely and appeared to be well. They remained 

 small and below the average in weight. Three were 

 males and one was a female. 



One of the males was mated with a normal female and 

 two normal young resulted. He was then mated with a 

 female from an alcoholic father and she gave birth to 

 two small young; one of these offspring was only half 

 size and very excitable. He was then mated with a 

 female from an alcoholic mother and one small young 

 was produced. 



A second one of the three males was mated with a 

 normal female which produced one large apparently 

 normal offspring. He was then mated with a female 

 from an alcoholic father and two small young resulted, 

 one of which died within five days and the other is weak 

 and nervous. He was again mated with a normal female 

 and one normal young was produced. 



The third male was mated with his sister and she gave 



birth to 3 young. One of the young died when one day 



