No. 563] EFFECT OF INTOXICATING MALE PARENT 665 



to the modified condition of the germ cells of the grand- 

 father from which they descended. 



Consideration of Individual Matings and Responses 

 Studying the data of individual animals, another point 

 of some importance presents itself. This is the fact that 

 the same male often yields very different results when 

 bred to different females, although the females are simi- 

 lar so far as the experiment goes, being either all normal 

 or alcoholic. This may be due to the varying degrees of 

 resistance or hardiness possessed by the germ cells of 

 different individuals. A part of this difference may be 

 due to the fact that as the treatment advances the germ 

 cells are more affected and the results do actually become 

 more pronounced. 



Male No. 5 that has been treated with alcohol for two 

 and one half years, has been mated 25 times. Eleven of 

 these matings have yielded negative results; 4 were with 

 alcoholic females and 7 were with normal. Three of the 

 matings gave stillbirths, 2 with normal females and one 

 by an alcoholic female. Only 11 of the 25 matings gave 

 living litters, 4 of these were non-viable and 7 litters 

 survived. Five of the 7 surviving litters were from nor- 

 mal females and 2 from alcoholic mothers. This alcoholic 

 male has, therefore, begotten only 7 surviving Utters out 

 of the 14 full term litters born and out of a total of 25 

 matings. 



Alcoholic male Xo. 6 shows a still worse record. Out 

 of a total of 21 matings, 10 have given negative results, 

 5 by normal and 5 by alcoholic females. Two matings 

 gave stillborn litters, one from a normal female and one 

 from a second generation female. Nine living litters 

 resulted from the 21 matings, 3 from alcoholic females 

 and 6 from normal. Five of the nine litters born alive 

 were non-viable, the young dying soon after birth. Only 

 4 litters survived out of the 11 reaching term and out of 

 the total of 21 matings. Three of these surviving litters 

 were from normal females and one was from an alcoholic 

 mother. 



