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THE AMERICAN NATURALIST [Vol. XLVII 



The one mating between two alcoholic individuals again 

 gave negative results. 



Thus 4 of the 18 matings failed to take, 3 of these were 

 between second generation animals and the fourth was 

 the double alcoholic mating. 



Fourteen matings were successful, in five cases one 

 member of the pair was normal and in seven cases both 

 were normal. In the remaining two cases both animals 

 were of the "second generation, " though themselves un- 

 treated, one litter was non-viable and but a single litter 

 of one young survived. 



These sample notes from 29 pairs out of the total of 

 167 full term matings contained in Table I, gives a fairly 

 clear idea of the manner in which tin- individual animals 

 respond. 



Conclusions 



Finally, in conclusion, we may consider the type or 

 nature of the injury produced by the treatments and the 

 manner of transmission or inheritance involved. The 

 treated animals themselves show no effects of nervous or 

 systemic injuries in their general health or behavior. It 

 is only when such individuals are bred that they prove to 

 be inferior to the untreated animals. This inferiority is 

 shown both by a slowness or failure in many cases to con- 

 ceive, although they copulate normally, and by the poor 

 quality of the offspring to which the successful concep- 

 tions give rise. That this poor quality of offspring is 

 due to an injury inflicted by the treatment on the germ 

 cells of the alcoholic animals is shown by the fact that 

 when the male alone is treated the offspring he begets 

 are decidedly inferior. The germinal taint is still further 

 demonstrated by the fact that the offspring from treated 

 parents although themselves not treated produce equally 

 or more defective young than do the treated animals. 



The defects shown by the offspring of alcoholic parent- 

 age are general in type, not definite or specific. The 

 central nervous system and special sense organs are 



