No. 563] EFFECT OF INTOXICATING MALE PARENT 679 



per cent., of the matings produced litters of living young, 

 containing a total of 54. Twenty-one, or almost 40 per 

 cent., of these young animals died within a few days or 

 less than four weeks after birth and only 33 of them sur- 

 vived. Many of the 33 survivors are small excitable 

 animals and though not treated themselves have usually 

 given rise to defective offspring in the several cases 

 where they have been mated with one another. 



The second eonihinat ion is between alcoholized females 

 and normal males, the results of which are interesting in 

 comparison with the above. In this combination there 

 are two chances to injure the offspring; in the first place 

 it may arise from a defective egg cell, or secondly, it may 

 be injured by an abnormal developmental environment 

 within the body of the alcoholized female. Fifteen such 

 matings have been made. Three of these, or 20 per cent., 

 gave negative results, or were possibly aborted very 

 early. Three stillborn litters of nine individuals were 

 produced. Sixty per cent, of the matings gave living 

 litters, as against 44 per cent, in the first combination 

 between treated males and normal females. The propor- 

 tion of surviving young is, however, less from the treated 

 females than from the treated males. Of V.) living young. 

 9 died soon after birth and 10 survived. 



The third combination was between alcoholized males 

 and females. Twenty-nine such matings gave in 15, or 

 more than 50 per cent., of the cases negative results or 

 early abortions. Three stillborn litters occurred, each 

 consisting of two individuals. Only 11 living litters were 

 produced containing 16 young, 9 of which survived while 

 7 died soon after birth. 



All of the matings of the treated animals may be com- 

 bined and compared with control matings as follows : In 

 a total of 103 full term matings, 43, or almost 42 per cent., 

 have given negative results or early abortions, while 35 

 control matings failed in only two cases, or about 6 per 

 cent., to yield a full term litter. Fourteen, or 13* per 

 cent., of the matings gave stillborn litters consisting of 



