THE AMERICAN NATURALIST [Vol. XL VII 



30 dead individuals. Only one stillborn litter occurred in 

 the 35 control matings ; this was a large litter of 4 indi- 

 viduals and the mother seemed almost unable to carry 

 them. The 103 matings gave only 46 living litters, about 

 45 per cent., while 32 living litters, or 91| per cent., were 

 produced by the 35 control matings. 



The 46 living litters from the alcoholic matings con- 

 tained 89 young, 37 of which died shortly after birth and 

 52 survived. The 32 living litters from the normal ani- 

 mals consisted of 60 individuals only 4 of which died 

 while 56, or 93 per cent., of them survived. 



Of 119 full term young, living and stillborn litters, pro- 

 duced by the alcoholic animals only 52, or less than 44 

 per cent., survived as against the 56, or 87|- per cent., 

 survivors among the 64 full term control offspring. 



The offspring derived from the alcoholic individuals 

 are termed second generation animals and were not them- 

 selves treated with alcohol. In three cases second gener- 

 ation individuals have been mated with normal and have 

 given perfect results, although the litters have been small. 

 It might seem as though the normal mate possessed a 

 strong tendency to counteract any defect which may have 

 been present in the second generation animal. 



Mating second generation individuals with alcoholized 

 guinea-pigs gave very different results. Two out of three 

 such matings produced stillborn young, one of which was 

 grossly deformed. The third mating gave two surviving 

 young. 



Nineteen matings have been made between second 

 generation animals, the outcome of which compares very 

 unfavorably with that from the control matings, while 

 the data are closely similar to those obtained from the 

 alcoholic matings. Seven, or almost 37 per cent., of the 

 matings gave negative results. Twelve living litters were 

 born consisting of 19 individuals, 6, or about 32 per cent., 

 of which died very soon after birth and showed various 

 nervous disorders ; one was entirely eyeless and decidedly 

 deformed. 



