1889.] On the local Paralysis of Peripheral Ganglia, Sfc, 429 



no fall of blood pressure. We conclude that the vaso-dilator as ivell as 

 the vaso- constrictor fibres of the splanchnic end in the cells of the solar 

 and renal plexuses. 



The connexion of the renal fibres with nerve cells, although it can 

 to a certain extent be deduced from observations like those we have 

 just given, is most satisfactorily made out. by noting directly the 

 volume of the kidney with the aid of Roy's oncometer. We have so 

 far only made this observation on the dog. In the dog copious appli- 

 cation of nicotin 1 per cent, to the ganglia of the solar plexus 

 does not prevent stimulation of the splanchnic from causing a normal 

 large constriction of the vessels of the kidney. This constriction, in 

 the few experiments we have made, has been as great as that occurring 

 before the application of nicotin to the solar plexus. On the assump- 

 tion that the constriction would be less if some of the vaso-constrictor 

 fibres had been put out of action, we conclude that few if any of the 

 splanchnic vaso-constrictor fibres for the kidney end in the ganglia of 

 the solar plexus. On separating the supra-renal capsule from the 

 underlying tissue, and applying nicotin to the ganglia which lie 

 underneath its lateral part, a decrease in the effect of splanchnic 

 stimulation occurs, and on brushing nicotin on the artery near the 

 supra-renal capsule there is a still further decrease in the effect. 

 Since the dogs on which we have experimented have had much 

 fatty tissue around the artery and vein, we have not succeeded in 

 laying bare the whole of the renal plexus' without some mishap, and 

 to this we attribute the fact that in the dog we have not obtained by 

 the application of nicotin a complete abolition of the vaso-constrictor 

 power of the splanchnic upon the kidney. Combining, however, the 

 oncometer observations on the dog with the blood pressure observa- 

 tions on the rabbit and cat, we think there is fair evidence that the 

 splanchnic vaso-motor fibres for the kidney end in the cells of the renal 

 plexus. 



The immediate effect of the application of nicotin to the ganglia of 

 the solar plexus is a rise of blood pressure and a dilation of the 

 kidney, followed by a fall of blood pressure and a constriction of the 

 kidney. The application of nicotin to the ganglia, of the renal plexus 

 causes a constriction of the kidney followed by a dilation, both being 

 greater than when nicotin is applied to the solar plexus, and with a 

 comparatively small effect on the blood pressure. Whilst normally 

 stimulation of the splanchnic in most cases causes a slight primary 

 dilation of the kidney, corresponding with the rise in blood pressure 

 from constriction of vessels of the stomach or intestine, after nicotin 

 has been given we have in no case observed a primary dilation of the 

 kidney or stimulation of the splanchnic. 



We have experimented upon various peripheral ganglia other than 

 those mentioned above, and, though our results are as yet incomplete, 



