484 



Prof. J. B. Hay craft. On the Action of a [Apr. 3. 



5.45 p.m. 1 cub. centim. of blood withdrawn, which remained 

 fluid until morning. 



6.5 p.m. 1 cub. centim. of blood withdrawn, which remained partly 

 fluid till morning. 



6.25 p.m. 1 cub. centim. of blood withdrawn, which coagulated m 

 25 minutes. 



7.0 p.m. 1 cub. centim. of blood withdrawn, coagulated in 5 

 minutes. 



During this experiment the respirations were somewhat increased 

 in number, a ad the temperature rose gradually until it reached 

 40° "1 at 7 o'clock. 



In the case of peptone injection a marked difference between its 

 effects on dogs and on rabbits is seen. A rabbit was therefore next 

 cbosen for the subject of an experiment. A. cannula was inserted 

 into the carotid for the purpose of withdrawing blood at intervals. 



1 cub. centim. of blood withdrawn. Coagulated in 0"8 minute. 



4.40 p.m. 5 cub. centims. of solution from 5 leeches injected into 

 left jugular vein. 



4.45 p.m. 1 cub. centim. of blood withdrawn from the carotid. It 

 remained fluid for 12 hours. 



4.47 P.M. 1 cub. centim. of blood withdrawn from the carotid. A 

 moiety coagulated in 2 hours. 



5.20 p.m. 1 cub. centim. of blood withdrawn. In 25 minutes 

 almost completely clotted. 



5.40 p.m. 1 cub. centim. of blood withdrawn. In 10 minutes it 

 clotted fast. 



6.0 p.m. 1 cub. centim. of blood withdrawn. In 3 minutes it 

 clotted fast. 



In my first experiments when an animal was allowed to live after 

 the operation, the wound in the neck was stitched up in the ordi- 

 nary way. When examined next morning a large swelling was 

 always observed in the region of the wound. On observing these 

 they were found to consist of imperfectly clotted blood which had 

 escaped from the divided capillaries, the fluid unable to clot had con- 

 tinued to collect often in very large amount, passing down under the 

 skin in front of the chest, and often causing death. Subsequently 

 the wound was carefully painted with perchloride of iron before 

 sewing it up, and no after-bleeding occurred. These facts are not 

 without interest, as they throw light upon a similar symptom seen in 

 many cases of hgemophilia or hemorrhagic diathesis, where the 

 slightest wound gives rise often to very troublesome bleeding. 



It was found by experiment that the injection of the leech extract 

 has no immediate action on blood pressure. After the injection of the 

 substance the animals as a rule appeared somewhat dull, the respira- 



