272 Dr. K H. Alcoek. On the Negative Variation [Jan. 17, 



CO,. 



Experi- 

 ment and 

 plate No. 



Neg. var. 

 before 

 in 0-001 

 : volt. 



Neg. var. 

 during 

 C0 2 . 



Neg. Tar. 

 after. 



Notes. 



202 



0-59 



o-i 



-3, -66, -53 



Kitten. L. sciatic. 3 h. 







3 min. 



post - mortem. Temp. 

 = 30°. Primary dimi- 

 nution and secondary 

 augmentation. 



A 1 406 



0-39 



-29 to -15 

 4 min. 



0-16 to 0-61 



Eabbit. R. sciatic. 3 h. 

 45 m. post - mortem. 

 Temp. 22° C. As 202. 

 Marked secondary aug- 

 mentation. FIG. 4. 



A> 405 



70 



-56 to '3 

 5 min. 



0'35 to 0*97 



Rabbit. L. sciatic. 1 h. 

 10 m. post - mortem. 

 As 406. 



E m 418 



0-32 



-3, -42, -29 

 6 min. 



-64 to -33 



Pigeon. L. sciatic. 3 h. 

 post . mortem. Temp. 

 = 37° C. 



Tetanisation. 



Ai 409 



2*5 



• 



Tet. 5 min. 



2-4 



Rabbit. Branch of R. 

 ant. crural. Temp. 

 27 5. 1 h. post-mor- 

 tem. 



A r 410 



2 3 



Tet. 6 min. 



i-8 



Rabbit. Do., do. L. 

 Temp. = 21°-5. 



A" 407 



0-90 



Tet. 5 min. 



0*85 to 0-96 



Rabbit. L. sciatic. 

 Temp. = 20°. 



A 1 411 



0-86 



Tet. 5 min. 



0-92 



Rabbit. R. sciatic. 

 Temp. = 27°. FIG. 5. 



Note.— -0005 volt corn- 

 pens, sent in after Tet. 1 

 2 k. 30 m. post-mortem. 



C cc 423 



0-26 



Tet 6 min. 



0-26 to 0-19 



Kitten. L. ulnar. Temp. 

 = 36° 5 C. 3 h. post- 

 mortem . 



The values are taken from photographs. The action of these drugs 

 on the nerves of warm-blooded animals is very similar to their effect 

 on the nerves of the frog. Chloroform, ether, and carbon dioxide all 

 produce diminution of the negative variation, followed by recovery in 

 the case of the latter, with recovery or not in the case of CHC1 3 , and 

 the details of the process are clearly to be seen in figs. 



The only difference that may be detected is that while in the frog 

 the negative variation is increased by " little " CHC1 3 or Et 2 0, and 

 the abolition by " much " CHC1 3 and EtoO is commonly followed by 

 recovery to or beyond the normal ; this increase has only been 



