1903.] 



On the Nucleoproteids of the Pancreas, etc. 



397 



enquiries. We trust, therefore, that during the next few months we 

 may be permitted to work out so far as we are able, the problems 

 which have been suggested by the new facts recorded in this paper. 



Supplementary Bibliographical Note. 



Since the above paper has been in print, it has come under the 

 notice of one of us that the late Professor Alexander Schmidt, of 

 Dorpat, in his published researches on the coagulation of the blood, * 

 drew attention to the fact that among the soluble constituents of 

 protoplasm was a body to which he gave the name of " Cytoglobin," 

 and which he found to be dextrogyrous. So far as we are aware, this 

 observation of A. Schmidt has never been noticed or quoted, either by 

 systematic writers on physiological chemistry or by those who have 

 devoted their attention to, or written upon, the subject which formed 

 the life-work of the Dorpat professor. There can be no question that 

 Schmidt's cytoglobin was an exceedingly impure mixture of nucleo- 

 proteids, an opinion which is based upon the fact that his substance 

 contained 12*52 per cent, of ash, and that, on ultimate organic 

 analysis, the amount of carbon found was 56 - 36 per cent., as compared 

 with 45 "83, the percentage of carbon in the nucleoproteid of the 

 pancreas. Still the fact remains that this indefatigable worker, whose 

 suggestive writings have been too little read, left data which prove 

 that the so-called " Cytoglobin " was nucleoproteid in nature, though 

 in no sense a definite proximate principle, and that this impure mixture 

 of nucleoproteids was characteristically dextrogyrous. 



March 4, 1903. A. G. 



* Alexander Schmidt, ' Zur Blutlehre,' Leipzig, Verlag v. F. C. W. Yogel, 1892. 

 Eefer to the chapter entitled " Ueber den in Wasser loslichen Bestandtheil des 

 Protoplasmas," &c. (pp. 127 — 142) ; ' Weitere Beitraege zur Blutlehre ' (nach des 

 Yerfassers Tode herausgegeben). Wiesbaden, J. F. Bergmann, 1895. Refer to 

 the chapter entitled " Zur Kenntniss des Protoplasmas uud seiner Derivate " 

 (pp. 201—249). 



VOL. LXXI. 



