70 



Mr. S. Vincent. 



Exp. 1. — Material taken from a fair-sized Specimen of Galeus canis. 



Large Bufo vulgaris. Fluid had been running about 30 minutes, 

 pressure 25 cm. 



Time. 



Outflow m 

 c.c. 







Time. 



Outnow m 



CO. 





4*40 



55 



Normal saline. 



5-35 







32-0 f 



" Paired segmen- 



4*45 



50 





5-40 



50-0 \ 



4-50 



50 





5-45 



20-0 L 



tal" suprarenal. 



4'55 



50 



" Interrenal." 



5*50 



2-5 





5-0 



33 





5-55 



1-5 





5-5 



11 





6-0 



2-5 



Normal saline. 



5 -10 



5 





65 



1-5 





5-15 



6 





6-10 



4-5 





5-20 



6 





6-15 



0-5 





5 25 



7 





6-20 



0-5 





5'30 



24 



Normal saline. 



6'25 



0-5 





Flow does not return to normal, although, a much longer time is allowed to 



elapse. 



Exp. 2. — Material from Gadus ceglefinus, Molva vulgaris, and Pleuro- 



nectes platessa. 



Large Bufo vulgaris. Fluid bad been running about 45 minutes, 

 pressure 30 cm. 



Time. 



Outflow in 

 c.c. 





Time. 



Outflow in 

 c.c. 





1 -45 

 1-50 

 1-55 



58 

 95 

 90 



Normal saline. 



Suprarenal extract 

 from Gadus cegle- 

 finus, then imme- 

 diately from 

 other two. 



2-0 



2-5 



2-10 



2-15 



2-20 



2'25 



2-30 



90 



85 1 Fresh saline. 



85 



93 



95 



94 



95 



There seems no reason to doubt that the active material in the 

 " medullary glands " of Elasmobranch fishes is the same as that in 

 the medulla of mammalian suprarenal, but so little of the material is 

 procurable for chemical analysis that I have found it impossible to 

 compare its reactions with that obtained from the higher animals. 

 It is worth noting, however, that the extract in water or alcohol is 

 of a pale brown tint, exactly resembling that of the medulla of 

 mammals.* But that this brown pigment is not the active substance 



* These glands become dark brown when treated with a solution of bichromate 



