388 Mr. J. N. Langley and Mr. W. L. Dickinson. [Mar. 27, 



to be effective on the constriction of the vessels of the ear and on the 

 secretion of saliva. 



The other effects of stimulating the cervical sympathetic are, how- 

 ever, more easily suppressed by nicotin. The one most readily 

 abolished is the flushing of the lips. With regard to the relative 

 ease of paralysis of the movements of the eye, eyelids, nictitating 

 membrane, and pallor of the mucous membrane of the mouth, we 

 have made a few experiments only, so that we cannot speak of them 

 with much confidence. The order, so far as our experiments go 

 (cf. Exp. VI), is movement of the eyelids, movement of the 

 nictitating membrane, pallor of the lips. 



Experiment VII. 

 Dog (C. p. 11). Morphia. Chloroform and ether. 



Left sympathetic separated from vagus for about an inch below superior cervical 

 ganglion, ligatured, and cut. With secondary coil at 10 (c = 10), the shocks are 

 distinctly felt on the tongue, but are not strong ; with secondary coil at 6 (c = 6), 

 the shocks are strong to the tongue. Stimulation of sympathetic with c = 10 

 causes flushing of lips and gums. 



1.26. Inject into femoral vein 50 mgm. nicotin. 



1.29. Stim. sy., c = 10, 20 sees. ; no effect on eye or lips. 



1.34. Stim. sy., c = 6, 30 sees. ; no effect on eye or lips. 



1.36. Stim. sy., c = 8, 60 sees. ; lips slowly become pale on both sides, but this 



may be the after-effect of nicotin ; no other change. The eye quickly 



shuts on touching the skin near it. 

 1.43. Stim. sy., c = 8, 60 sees. ; pupil dilates — it was large before stimulation. 

 1.52. Stim. sy., c = 8, 60 sees. ; pupil dilates readily, no other change observed; 



on left side lips are very pale, and the nictitating membrane is partially 



drawn back ; on right side Hps are pinkish, and nictitating membrane is 



§ to i way over the eye. 

 2.10. Stim. sy., c = 8, 60 sees.; edges of lips become paler. 

 2.16. Stim. sy., c = 8, 60 sees. ; momentary movement of nictitating membrane. 



2.35. Stim. sy., c — 12, 30 sees. ; eye opens. 



2.37. Stim. sy., c — 7, 30 sees. ; lips slightly flush for 10 to 15 sees., then become 



pale. r 



An interesting result is often obtained by stimulating the sym- 

 pathetic after a rather larger dose of nicotin ; in this case, the pupil 

 is rather large, the eye is turned forwards, and the eye is open, but 

 not widely ; stimulation of the sympathetic then causes the eyelids 

 slowly to approach one another, i.e., the eye, instead of opening, 

 becomes more closed. The movement is chiefly in the lower eyelid. 

 On ceasing the stimulation the eye gradually opens to its previous 

 extent. The closing of the eye on stimulating the sympathetic occurs 

 at a time when the stimulation still produces dilation of the pupil and 

 secretion of saliva. It will be remembered that Rogowicz* observed 

 occasionally a similar closing of the eye in the dog when the sym- 



* ' Archiv f. d. ges. Physiol.' (Pfluger), vol. 36, 1885, p. 7. 



