1890.] Secretion of Bile in a Case of Biliary Fistula. 505 



Chart 3. 



12 oz. 6 dr. 20 min. of bile were excreted, and that for ten honrs sub- 

 sequent to the administration 10 oz. 4 dr. 30 min. were excreted, i.e., 

 2 oz. 1 dr. 50 min. less. 



Euonymin. — On "Nov. 17th 4 gr. of euonymin were given at 

 11*30 A.m. ; for the four hours preceding the administration, 

 5 oz. 4 dr. 9 min., and during the four hours subsequent to its 

 administration, 5 oz. 1 dr. 8 min., were excreted, i.e., 3 dr. less- 

 This dose was repeated on several occasions with similar results. 



Rhubarb. — On Nov. 13th, at 11 a.m., i oz. of tincture of 

 rhubarb was administered ; during the preceding six hours 



7 oz. 3 dr. 23 min. of bile were excreted, and during the six hours 

 subsequent to the administration of the drug, 7 oz. 4 dr. 19 min. 

 were excreted, that is 56 mins. more, in the subsequent than in the 

 preceding six hours. But on comparing the corresponding period of 

 the previous day, when no rhubarb was given, we find that 



8 oz. 6 dr. 10 min., or 1^ oz. more, were excreted. Therefore no 

 increased flow of bile can be put down to the action of the rhubarb. 



On Nov. 15th, 1 oz. of tincture of rhubarb was given. The figures 

 as seen in the tables again show a diminution compared with tfye 

 previous day. 



Podophyllin was given on one occasion, and no cholagogue effect 

 was noticed. 



Carbonate of Soda. — Soda water, aerated, was given, and produced 

 an increased flow. Its ingestion was followed in two hours by a 

 maintained increased flow not succeeded by a marked diminution. 



Iridin. — On April 16th, 4 gr. of iridin was followed by a good 

 afternoon rise in the bile flow, but two days later there was a much 

 higher afternoon rise when no drug had been given. On April 19th, 



