1892,] The Influence of the Kidney on Metabolism. 



31 



From this table it will be seen that the second operation is followed 

 by a great increase in the amount of urine excreted, and also by a 

 large increase in the output of nrea. The increase in the urinary 

 water, however, is greater than the increase in the urea, although 

 the latter, as seen above, is greatly augmented. 



This condition of polyuria is accompanied by great wasting. 



Thus the weight of Dog No. 6 fell from 11 lbs. to 8 lbs. in 50 days. 



No. 9 



?j 



15 



„ io 



» 18 „ 



No. 12 



»> 



19 



„ 12 



?? 15 ? i 



No. 23 



5J 



11 



„ 7 



» 25 „ 



This wasting is rapid in its course, and is not materially checked 

 by a liberal diet, when the animal's appetite will admit of it. The 

 appetite frequently fails somewhat, but the animals will eat meat 

 in large quantities to within a short time of their death, although 

 they refuse dog biscuit. There is also great thirst, and this, no 

 doubt, is in close relation with the hydruria. When the polyuria is 

 fully established, the rectal temperature falls, so that ultimately it 

 may be as low as 97° F., or even 95° F., the normal temperature 

 varying between 101° F. and 102° F. This condition of polyuria 

 leads to a more or less rapid death ; all the animals in Table II either 

 died, or were killed because moribund, in from two to six weeks after 

 the second operation. 



The following table gives the results in the remaining six cases 

 out of the ten rapidly fatal cases : — 



