70 



Dr. E. F, Bashford and Mr. J. A. Murray. [Jan. 12, 



The following points are of great importance in these observations. 

 A complicated sequence of cell-changes has been found to be charac- 

 teristic of carcinoma and sarcoma alike. This sequence is the same 

 as that which initiates the origin of the sexual generation in plants 

 from the asexual, and is terminal in the history of the sexual cells in 

 animals. It must be noted also that all the cells of the malignant 

 new growths do not undergo the reducing division, a certain number 

 differentiate in the direction of the tissue among which they 

 have arisen, and in the secondary growths when present, somatic 

 mitoses occur in the growing margin, which it will subsequently be 

 shown is also a feature in the growth of cancer when transferred to a 

 new host. 



Fig. 4. — Heterotvpe ampliiaster, chromo- 

 somes arranged longitudinally on 

 spindle. Eeduced number. All the 

 chromosomes are not figured. 



Fig. 5. — Heterotype amphiaster. Ring 

 chromosomes, 12 in number. Adeno- 

 carcinoma of Mouse. (The nucleus 

 was contained in two consecutive 

 sections). 



The Transmissibility of Malignant New Growths from one Animal to 



Another. 



The transmission of cancer from man to animals, or from one 

 animal to another of different species, has never been successfully 

 performed. Successful transplantation experiments have been made, 

 however, from animals suffering from malignant new growths to 

 others of the same species. The most exhaustive observations in this 

 connection have been made by Jensen and Borrel on mice. Professor 

 C. 0. Jensen, of Copenhagen, most generously placed at the disposal of 

 the Cancer Kesearch Fund a portion of one of his experimental 

 tumours,* and with this, and another tumour occurring naturally in a 

 tame mouse, similar experiments have been performed. We have 

 thus been able to confirm Jensen's observations by microscopical 

 examination of the tissues at the site of inoculation at short intervals, 

 and have found that the new tumours which develop arise from the 

 actual cells introduced. While many of these degenerate, a few 



* Sent by post under such precautions as to preserve sterility. The trans- 

 plantations were effected by the Cancer Research Fund five days after the tumour 

 was posted in Copenhagen. 



