1904.] On the Lymphatic Glands in Sleeping Sickness. 



455 



A large number of temperature coefficients have been measured. 

 These were found to be in the majority of cases positive, i.e., the 

 conductivities increase with rise of temperature. 



All the experiments which have been hitherto carried out lead to 

 the conclusion that it is the dissolved substances (i.e., the acetamide, etc.) 

 which carries the current and not the halogen hydride. In other words, 

 we are dealing with solutions in which the organic and not the inorganic 

 substance undergoes electrolytic dissociation. 



Further experiments are at present in progress, having for their 

 object the measurement of the molecular weight of the dissolved 

 substances (Mcintosh and Archibald) and the determination of the 

 transport numbers (Steele). 



Discussion of the results so far obtained is deferred until these 

 experiments are completed. 



xt Xote on the Lymphatic Glands in Sleeping Sickness." By 

 Captain E. D. W. Geeig, I.M.S., and Lieutenant A. C. H. 

 Quay, K.A.M.C. Communicated by Colonel Bruce, F.B.S., 

 at the desire of the Sleeping Sickness Commission. Eeceived 

 and P^eacl May 5, 1904. 



Captain Greig, in a letter elated March 17, 1904, writes that 

 following a suggestion of Dr. Mott, they have examined the contents 

 of lymphatic glands during life from fifteen sleeping-sickness patients. 

 In all of them actively motile trypanosomes were very readily found 

 in cover-glass preparations taken from the cervical glands. They were 

 also present in other glands such as the femoral, but were not nearly 

 .so numerous. 



They found the trypanosomes to be far more numerous in the 

 glands than in the blood or cerebro-spinal fluid, and believe that the 

 examination of fluid removed from lymphatic glands will prove to be 

 a much more rapid and satisfactory method of diagnosing early cases 

 -of sleeping sickness than the examination of the blood. 



At first the glands were excised, but this was soon found to be 

 unnecessary, as it is easy to puncture a superficial gland with a hypo- 

 dermic syringe and suck up some of the juice into the needle and blow 

 this out on a slide. The actively moving trypanosomes were readily 

 found after a short search in these slides, when a prolonged search 

 in similar preparations of the blood from the finger failed to discover 

 them. In stained specimens, in addition to well-formed trypanosomes, 

 there exist many broken-down remains, which suggests that a destruc- 

 tion of the trypanosomes takes place in the glands. * 



