500 



Mr. H. Swithinbank. Effect of Exposure to 



Results of Subcutaneous Inoculation into the Guinea-pig of J c.c. of 

 an Emulsion in Broth of Contents of Tubes treated as above. 



Tubes. 



Treat- 

 ment. 



Animal 

 died or 

 killed. 



After 



Precis of post-mortem results. 



A. 



Six hours 

 without 

 contact 



killed 



100 days 



Tubercular. Deep inguinal glands much 

 enlarged and caseous. Liver enor- 

 mously enlarged and studded with 

 well-marked tubercles. Spleen much 

 enlarged and crowded with tubercle. 

 Peri-bronchial glands enlarged and 

 calcareous. Mesenteric glands en- 

 larged, and in some cases caseating. 

 Tubercle bacilli found. 



J3. 



Twelve 

 hours 

 without 

 contact 



killed 



100 days 



Tubercular. Grlands of left inguinal 

 region much enlarged and filled with 

 caseous matter. Liver congested and 

 permeated throughout with minute 

 tubercles. Spleen ditto. Rare tuber- 

 cles in lung structure. Peri-bronchial 

 glands enlarged, hard, and in some j 

 cases caseating. Tubercle bacilli 

 found. 



C. 



Twenty- 

 four 

 hours 

 without 

 contact 



died 



95 days 



Tubercular. Deep inguinal glands en- 

 ormously enlarged and caseous. Liver 

 hypertrophied and full of tubercle. 

 Spleen enormously enlarged and 

 crowded with tubercles. Lungs a 

 mass of minute tubercles. Tubercle 

 bacilli found. 



D. 



Twenty - 

 four 



with con- 

 tact 



killed 



100 days 



Tubercular. In left inguinal region an 

 enlarged gland the size of a pea, hard 

 and filled with caseous matter. Retro- 

 peritoneal glands enlarged and caseous. 

 Liver studded with tubercles. Gland 

 at hilus of liver the size of small hari- 

 cot and filled with cheesy pus. Spleen 

 of normal size, but studded with mi- 

 nute tubercles. Peri-bronchial glands 

 enlarged. Lungs studded with minute 

 tubercles. Tubercle bacilli found. 



E. 



Forty- 



eight 



without 

 contact 



killed 



100 days 



Tubercular. Subcutaneous abscess at 

 seat of inoculation. Inguinal glands 

 slightlv enlarged. Liver congested, 

 patchy, and crowded with tubercle. 

 Spleen permeated with minute tuber- 

 cles. Caseating nodule on hilus of 

 liver. Lungs covered with tubercu- 

 lous patches. Large caseating nodule 

 on superior sui'face of thorax. Peri- I 

 bronchial glands enlarged and caseat- 

 ing. Tubercle bacilli found. 



F. 



144 hours 



died 



78 days 



Tubercular. Inguinal glands enor- 

 mously enlarged and caseating. Liver 1 



