26 



On the Structure of the Cells of the Liver. [Apr. 27, 



Kayser,* on the dog. Bock and Hofmann found that glycogen 

 accumulated in amorphous form around the nucleus, and stretching 

 out from this as a network towards the periphery of the cell. My 

 own observations confirm this in the main. I regard, however, the 

 glycogen as being stored up in the spaces of a protoplasmic network. 

 Bock and Hofmann also mention granules of the liver-cells which 

 stain yellow with iodine, f but they do not appear to have distinguished 

 between these and the protoplasmic network which likewise stains 

 yellow with iodine. 



Kayser (he. cit.) found that glycogen was stored up in the form of 

 " Schollen oder Korner ;" these lumps and granules of glycogen I have 

 not seen ; an appearance simulating this occurs when the glycogen is 

 stored up more in some parts of the protoplasmic network around the 

 nucleus than in others, but these local collections never have, so far 

 as I have observed, sharpJy marked boundaries. The granules are not 

 distinguished by Kayser from the protoplasmic network ; these two 

 together make up^. I imagine, the thick peripheral layer of protoplasm 

 described by him as occurring in cells which contain much glycogen. 

 As in the liver of the frog, so in the mammalian liver, I take the 

 granules to be concerned in the formation of some of the substances 

 found in the bile. 



* Kayser. Quoted by Heidenhain. " Hermann's Hdb.," Bd. v, Th. 1, s. 221, 

 1880. 



f Similar granules were also described by. Plosz. " Pfluger's Archiv.," vii, s. 371, 

 1873. 



