THE 



AMERICAN NATURALIST 



Vol. L. February, 1916 No. 590 



A FUETHEE ANALYSIS OF THE HEREDITARY 

 TRANSMISSION OF DEGENERACY AND 

 DEFOEMITIES BY THE DESCENDANTS 

 OF ALCOHOLIZED MAMMALS 



CHARLES R. STOCKARD and GEORGE PAPANICOLAOU 



DEPARTilEHT OF ANATOMY, CORNELL UNIVERSITY MEDICAL SCHOOL, 



and from maternal alcoholized ancestors. 

 General considerations. 



Introduction 



A little more than two years ago the senior author 

 (Stockard, '13) recorded in this journal experiments 

 which had then been running for three years and seemed 

 to show a definite injury of the germ cells by treating 

 mammals with the fumes of alcohol. This injury of the 

 male germ cells is of such a nature that an alcoholized 

 male guinea pig almost invariably begets defective off- 

 spring even when mated with a vigorous normal female. 

 A t that time it was also shown that F l animals, the off- 

 spring of treated parents, though themselves not treated, 

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