84 



THE AMERICAN NATURALIST 



[Vol. L 



had one or both eyes deformed (Figs. 1 and 2), and two 

 were anophthalmic monsters, being completely without 

 eyeballs, optic nerves, optic chiasma or any gross signs 

 of optic tracts (Fig. 3). The brains are now being 

 studied in sections. Figs. 1 to 3 illustrate animals show- 

 ing the different eye conditions— asymmetrical eyes, mon- 

 strum monophthalmicum, and anophthalmic monsters. 

 Figs. 5 and 6 of Plate III illustrate the brains of a normal 

 and an anophthalmic specimen for a comparison of the 

 condition of the optic nerves, etc. 



Forty-six full-term young were produced by the F 2 

 matings, but only 13 of these, or just 28 per cent., were 

 able to survive, while about three times this proportion, 

 or 78.5 per cent, of the full-term young from control mat- 

 ings, survived as vigorous healthy individuals. The 13 

 living F 3 animals are all rather weak and degenerate and 

 almost completely sterile according to a considerable 

 number of careful matings with strong, fertile guinea 

 pigs. The alcoholic race seems at this stage of the ex- 

 periment about to fade out in the fourth generation, while 

 normal control lines from the same original stocks have 

 passed far beyond this generation, continuing to breed 

 normally and showing no signs of degeneracy, and never 

 in any case giving rise to a grossly deformed animal. 



The eleventh line indicates again the very decided ef- 

 fects transmitted by the descendants of animals which 

 had suffered a modification of their germ plasm by the 

 alcoholization of their tissues. In 33 cases F, and F 2 

 animals were paired together. Fifteen of these matings 

 gave negative results or early abortions, while about 12 

 per cent, of the matings resulted in stillborn litters of two 

 young each. Only 14 living litters were produced bv the 

 33 matings; these contained in all 23 young, only* 7 of 



only 7, or about 22 per cent., were capable of mvJivmg. 

 All of these young animals are nervous and weak and 

 several offspring from these combinations were deformed. 

 When F 2 animals are mated with normal individuals 



