16 



Especially have Lindt (39) and Lichtheim (37, 38) made \aluable 

 contributions to this subject. 



Mycosis of the digestive apparatus has been reported several 

 times. MoHLER and Buckley (42) quote Frank (1890) and Lucet 

 (1897) both having found intestinal aspergillosis in animals. They 

 also refer to Geni, who records a number of instances in man. 

 EiNHORN (13) reports four cases of gastric mjxosis in persons 

 suflfering with h3'perchlorhydria and figures the fungus, which in 

 all probability is an Oidium. Also Otto (46) mentions a case of 

 mycosis intestinalis and gives references to a number of other cases 

 reported in the medical literature. Both Otto (46) and Renon (52) 

 succeeded in producing the disease experimentally by feeding 

 animals with spores of Aspergillus famigatus. 



7. Intravenous Injections in Rabbits of certain 

 Intestinal Moulds. 



As at least three of the fungi found in the alimentary canal of 

 man, namely Aspergillus terreus, A. umbrinus, and Penicilliiim 

 divaricatum have never before been reported as occurring within 

 the human body, and furthermore, as considerable theoretical in- 

 terest is connected with the question of the pathogenit}^ or non- 

 pathogenity of these species, injections were made intravenously in 

 rabbits, of spores of these moulds. The results of the injections 

 are given below. 



Rabbit i. 0.25 c. c. of spores of Penicillium divaricatum were 

 injected in the middle ear vein. No mycotic symptoms were seen 

 at the end of two weeks. 



Rabbit ii. O.s c. c. of spores of P. divaricatum were injected in 

 the same vein. The animal remained alive. When killed and 

 examined at the end of two weeks, the kidneys, lungs, and the 

 liver were found to be perfectly normal. 



Rabbit iii. 0.5 c. c. of spores of Aspergillus terreus were injected 

 through the middle ear vein. The animal remained perfectly 

 healthy. 



Rabbit iv. O.s c. c. of spores of Aspergillus umbrinus w^ere injected 

 through the same vein. An}^ mycotic symptoms could not be 

 noticed at the end of two weeks. 



