39 



therplant is able to form its alcaloid anew inside of 

 twelve hours. 



V. Empty eut leaves also are able to form alcaloid inside 

 of a few days at least. 



It will therefore be allowed to draw thèse conclusions: 



A. The disappearance of the alcaloid from the leaves is 

 due to transportation towards the stem. 



B. The alcaloid later on found in a previously empty 

 leaf, has been made by that leaf itself. 

 Consequently: The alcaloid présent in the bark of Cincho- 

 na has been formed in the leaves, transportée! in small 

 quantifies towards the stem and there stored away. 



From the microchemical investigation we know that it 

 is transportée! as a fluid, stored up as an amorphous solid. 



We know from analyses made by Broughton that the 

 leaves of Cinchona Succirubra contain quinine besides the 

 other alcaloids, sothat transportation of that substance 

 would account for the quinine présent in the bark. 



Yet we know that transformation of the alcaloid must 

 take place in the bark itself in as much as de Vrv and 

 Behrens have found that the leaves of C. C. Ledgèriana 

 contain no crystallisable alcaloids or i. o. w. no quinine, 

 while the bark contains such in large quanti ty. The lea- 

 ves of C. Ledgèriana contain nothing but amorphous al- 

 caloid and consequently we have to accept a transforma- 

 tion of amorphous alcaloid to crystallisable ones. 



A- transformation from an alcaloid to another is by no 

 mearis inconcéivable as quinine is known to be a cinchonine 

 derivative, through substitution of the groupe GH 3 0 for a 

 CH groupe.- The chemical name of quinine is paramethoxy-" 

 cinchonine. 



But even more, Grimaux and Arnaud ( x ) have made quK 



(!) C. R. 122. p. 774; 114. p 672" 



