40 



Scientific Proceedings (26). 



were found, but no general or isolated thrombosis. These lesions 

 were notably most extensive in the calcium lactate animal and least 

 so in the citric acid, but when the experiment was repeated under 

 similar conditions, exactly opposite results followed, which leads 

 us to believe that chance was really the controlling factor in deter- 

 mining these changes. 



Positive results have been obtained in but a single set of experi- 

 ments ; those were where terpentine was injected. 



In so far as the results of this preliminary study go, one is led 

 to the conclusion that thrombosis is most readily induced where 

 active inflammatory lesions exist in the blood vessels probably 

 associated in most instances with secondary degenerative changes. 

 Purely mechanical lesions are much less apt to be productive of 

 conditions favorable to thrombosis as a sequence of phlebitis. 



Marked artificial increase or decrease in the coagulation time 

 of the blood by the use of calcium lactate or citric acid, does not 

 render animals abnormally prone to thrombosis incited by changes 

 other than inflammatory. 



Where true phlebitis exists, thrombosis is apt to be more 

 extensive and less readily resolved, when the coagulation time of 

 the blood has been shortened by the use of calcium lactate, and 

 it is less extensive and more quickly absorbed where the coagula- 

 tion time has been increased by the administration of citric acid. 



Experiments as yet incomplete, appear to suggest that the 

 rapidity or slowing of the general circulatory flow has but little 

 bearing on the relative production of thrombosis in phlebitis, much 

 less than clinical and anatomical observations have generally led 

 us to think. We have also been led to suspect that the presence 

 or absence of anastomoses of abundant degree is largely concerned 

 as a factor in determining the location and extent of thrombosis in 

 phlebitis. 



