A Clinical Viscosimeter. 



47 



The fluid, the viscosity of which is to be determined, is drawn 

 into the pipette from a receptacle. By means of the usual method 

 the time is recorded which elapses between the dipping of the 

 pipette into the liquid and the moment when the fluid passes the 

 mark above the bulb. A comparison is then made between this 

 value and the value previously obtained for distilled water, the 

 latter being regarded as i. The experiments are performed at 

 room temperature. 



26 (282) 



Studies in experimental arteriosclerosis. 

 By ISAAC ABLER and 0. HENSEL. 



\_From the Laboratory of Dr. Isaac Adler, New York Cily^\ 



Some time ago we reported to this society 1 that the intravenous 

 injection of nicotin produced in the aorta of rabbits lesions practi- 

 cally identical with those obtained by Josue and others with intra- 

 venous injections of adrenalin. 



The following is a brief summary of our further experiments 

 along those lines. Many observers have laid particular stress upon 

 the fact that where macroscopic lesions are not found, minute mi- 

 croscopic changes, stretching of the elastica and the like, could 

 be recognized. We have counted as positive only such where 

 there were distinctly visible macroscopic lesions. All observers 

 agree that the best results can be obtained with older animals 

 weighing over 2,000 grams. It was our misfortune that the great 

 majority of rabbits obtainable by us were young and under the 

 weight mentioned. 



Twenty-four rabbits were treated with intravenous injections of 

 nicotin, the dose being 5 drops of a 1-200 solution of pure nicotin. 

 7 died before they had had a sufficient number of injections. Of 

 the remaining 17, results were positive in 7 after 18 to 77 injec- 

 tions. In 10 there were no macroscopic lesions after 20 to 117 

 injections. 



In 6 rabbits nicotin and euphthalmin were used. Five were 

 negative but one which had received alternate nicotin and euph- 

 thalmin injections 69 times showed aneurysm and calcification. 



1 Adler and Hensel : This journal, 1905, iii, p. 36. 



