4 8 



Scientific Proceedings (26). 



The euphthalmin did not alter the typical nicotin reaction, such as 

 convulsions, etc. 



Nine rabbits received intravenous injections of nicotin and sub- 

 cutaneous injections of iodipin. All were negative. 



Two rabbits received their nicotin subcutaneously, the dose 

 being double that given intravenously. One died too soon ; the 

 other was killed after 25 injections. Neither showed any arterial 

 lesions. 



One rabbit was given nicotin simultaneously with 1/10 grain 

 atropin. It died after 14 injections ; negative. 



One nicotin and amyl nitrite ; negative. Convulsions in no 

 way influenced by these drugs. 



Four rabbits were given nicotin and sodium nitrite ; 3 negative 

 and one positive after 49 injections. Two in which nicotin was 

 injected into the peritoneum died after a few injections from some 

 infection. 



Two were fed by mouth with nicotin solution commencing 

 with 5 drops and gradually increasing to 60. They were killed 

 after 68 feedings. Result was negative. 



Our series comprises 52 rabbits in all with 9 positive results. 

 Excluding the 9 rabbits treated with iodipin and not counting all 

 those experiments in which the animals died or were killed before 

 a sufficient number of injections could be given, 23 in all, there 

 remain 29 negative to 9 positive results. 



Eight rabbits were treated with adrenalin of which 5 died after 

 I to 8 injections ; the other 3 after 29, 63 and 82 injections showed 

 aneurysms and calcifications. 



Five rabbits were treated with barium chlorid, 5 to 10 minims 

 of a 1 per cent, solution. Two of these died after 3 injections, 

 possibly from over-dose ; the other three after 40, 65 and 69 

 injections were negative. 



Two received barium chlorid and iodipin. One died after 2 

 injections from over-dose. The other, after 61 injections, showed 

 no lesion. 



One rabbit received 63 injections of euphthalmin with negative 

 result. The dose, 3 milligrams, was probably too small. 



Two treated with intravenous injections of calcium chlorid after 

 74 injections showed no lesion. 



