Twenty eighth meeting. 



Physiological Laboratory of the New York University and Bellevue 

 Hospital Medical College. April 75, igoS. President 

 Lee in the chair. 



39 (295) 



Influence of cold and exercise in phlorhizin glycosuria. 



By GRAHAM LUSK. 



\From the Physiological Laboratory of the University and Bellevue 

 Hospital Medical College.] 



When phlorhizinized fasting dogs with a urinary D : N ratio of 

 3.65 : 1 are exposed to cold they at first lose extra sugar which is 

 derived from body glycogen. But if the exposure to cold be re- 

 peated the D : N = 3.65 : 1 may remain unaltered. 1 The lowering 

 in environmental temperature was such as would increase fat com- 

 bustion in the animal by 50 per cent, and yet the sugar output 

 remained unchanged. 



Mechanical work at first brings about an increased sugar ex- 

 cretion. If, however, a dog be freed from glycogen mechanical 

 work has no influence on the sugar excretion. In the following 

 experiment a fasting dog was made use of on the third day of 

 total phlorhizin glycosuria. He was prepared by administering 

 cold baths on the first and second days of the glycosuria, and 

 then exposing him to a temperature of io° C. ; shivering re- 

 moved his surplus glycogen. The mechanical work was done in 

 a wheel during five-minute intervals of alternate work and rest 

 throughout a first hour of a two-hour period. The results were 

 as follows : 



Period in Hours. 



Distance Travelled 

 in Meters 



D 



N 



D : N 



2 







4.20 



1. 19 



3-53 



2 



1,500 





5-32 



1.36 



3-90 



2 







4-57 



I.26 



3-63 



2 



1,500 





4.62 



I.26 



3-67 



•Confirms Brasch, Minkowski, Allard; opposes Liithje. 



(71) 



