7 2 



Scientific Proceedings (28). 



The fat metabolism during the hour of work must have been 

 double that of an hour of rest, and yet in the last experiment 

 there is absolutely no change whatever in the sugar excretion as 

 a result of travelling 1,500 meters. The D :N ratio is therefore 

 absolutely independent of fat metabolism, but is dependent upon 

 protein metabolism. 



To illustrate the manner of sugar production from protein, 

 glutamic acid with its five C atoms was administered subcutane- 

 ously and per os to a phlorhizinized dog. The resulting increase 

 in the output of urinary sugar was such as would indicate cer- 

 tainly a conversion of three and possibly a conversion of four of 

 the carbon atoms of glutamic acid into dextrose. One can explain 

 the former case as a result of the cleavage of glutamic acid into 

 an alanin radicle which is convertible into lactic acid in metabolism 

 and this again into dextrose. 



The writer was assisted in this work by Mr. H. P. Mencken. 



40 (296) 



The influence of carbohydrate on the protein metabolism of a 

 fasting pregnant dog. 



By J. R. MURLIN. 



[From the Physiological Laboratory of the University and Bellevue 

 Hospital Medical College^ 



A dog in the ninth week of pregnancy and weighing 12.46 

 kgm., on the third fasting day of a three-day period was fed 42 

 gm. of cane sugar for two days. The reduction in the nitrogen 

 elimination on the second sugar day as compared with the last 

 fasting day was over 50 per cent. The same experiment was re- 

 peated on the same dog more than two months later, i. e., four 

 weeks after the puppies were weaned. The dog weighed on the 

 third fasting day 10.42 kgm. Since the puppies when they were 

 born (four days after the conclusion of the former experiment) 

 weighed 1.5 kgm., this probably represents, as nearly as one can 

 estimate, the weight of the mother alone at the time of the former 

 experiment. The cane sugar fed, therefore, would represent about 

 the same percentage of the actual requirement on the part of the 



