Thrombosis in Phlebitis. 



39 



within twelve hours by edema and an active inflammatory exuda- 

 tion with thrombosis of the involved vein in all three animals. 

 The thrombosis was notably more extensive and resolution most 

 delayed in the animal which had received the calcium lactate, less 

 so in the control and least of all in the rabbit which had been 

 poisoned with citric acid. 



The same relations as regards severity and occurrences of 

 lesions followed when 50 per cent, turpentine in inert oil was em- 

 ployed in the experiment except that the resulting inflammation 

 and subsequent thrombosis was longer delayed. 



Series II. Experiment a. — Fine comminuted sterile pumice 

 was injected into the marginal ear vein in an attempt to see if the 

 resulting thrombosis following probable embolism of the terminal 

 arterioles would be more extensive in those animals which had 

 received the calcium salt and less so in that which had received 

 citric acid. All three animals recovered perfectly from the ope- 

 ration and later autopsies showed no lesion whatsoever which 

 could be attributed to this injection. 



Experiment b. — Fifteen minims of sterile cod liver oil was 

 injected into the marginal ear veins of the three animals. None of 

 them showed symptoms and later post mortems showed no lesions 

 attributable to the experiment. 



Experiment c. — Two minims of a pure 24 hour culture of 

 virulent typhoid bacilli were introduced through the marginal vein. 

 No symptoms of illness followed and these animals were subse- 

 quently utilized in experiment d. These results are exactly con- 

 trary to those of Jakowski who in similar experiments in guinea 

 pigs and rabbits obtained almost constant thrombosis, but without 

 the associated employment of calcium or citric acid. 



Experiment d. — Fifteen minims of a suspension of a 36 hour 

 broth culture of virulent typhoid bacilli in an equal bulk of sterile 

 cod liver oil were introduced through the marginal vein. This 

 was done in the expectation that embolism caused by the oil 

 would be likely to afford sites for the growth of the bacilli and 

 probable resulting thrombosis as described in the experiments of 

 Jakowski. All the animals became seriously sick and on post 

 mortem examination multiple serous petechiae, general paren- 

 chymatous degeneration, lymphadenitis and frequent infarctions 



