38 



Scientific Proceedings (26). 



Experiment c. — A 2 cm. segment of the marginal vein was 

 clamped and isolated with paper clips for twelve hours, the anas- 

 tomosing circulation being meanwhile prevented. Immediately on 

 the removal of the clips the circulation was reestablished in all 

 animals, the absence of thrombosis in these experiments being like 

 the results of the experiments reported by Baumgarten and his 

 student Rizor who was able to compress the vein for an even 

 greater length of time without resulting thrombosis. After three 

 days considerable inflammatory reaction developed about the site 

 of some of the clamps, this being most marked in the calcium 

 lactate animal, where finally a small segment of the vein became 

 thrombosed. The inflammatory reaction was less marked in the 

 control animal and there was still less reaction in the citric acid 

 rabbit, thrombosis being absent in both. From these experiments 

 one may conclude that mere stagnation of the venous blood pro- 

 duced no marked tendency toward thrombosis in the ear veins but 

 that inflammatory lesions, with consequent phlebitis are more 

 extensive in the case of the calcium animal and thrombosis may 

 occur at the immediate point of injury of the vessel walls. 



Experiment d. — A quantity of 24-hour growth of virulent 

 pneumococci in bouillon was injected about the ear vein, the 

 injection being continued to such a point as to cause compression 

 anaemia of the desired segment of the vein. The circulation was 

 shortly reestablished and the amount of subsequent inflammatory 

 reaction was slight. No thrombosis occurred in any of the animals. 

 Our results in this experiment are therefore quite unlike those of 

 Von Talke where, however, the coagulation of the blood was not 

 altered, for Von Talke claims to have regularly produced throm- 

 bosis in this way. 



Experiment e. — Five minims of 5 per cent. AgN0 3 were 

 injected into the perivenous connective tissue of the ear. Im- 

 mediate permanent thrombosis of the adjacent vessels followed. 

 No difference in extent or degree existed between the three 

 animals. This experiment was repeated using 1 per cent, solu- 

 tions of AgN0 3 . Slight perivascular inflammation without throm- 

 bosis resulted and was of about equal severity in all the animals. 



Experiment f. — Three drops of pure turpentine was injected 

 between the branches of the median ear vein. This was followed 



