Transplanted Kidneys. 



19 



9 (265) 



Reestablishment of function in transplanted kidneys. 

 By ALEXIS CARREL. 



\_From the Rockefeller Institute for Medical Research^ 



Both kidneys, the left suprarenal gland, their vessels, their 

 nerves and ganglia, the corresponding segments of the aorta and 

 vena cava, the peritoneum, the ureters and a part of the bladder 

 were removed in one mass from a female cat and transplanted in 

 another female cat whose normal kidneys had been extirpated. 

 The circulation was reestablished through the new kidneys and 

 the flap of bladder sutured to an opening in the bladder of the 

 host. 



After this operation, the animal remained in excellent con- 

 dition. She walked and played like a normal young cat. She 

 was drinking milk and eating a great deal of raw meat. She 

 grew very fat and enjoyed good health. She urinated abundantly 

 — from about 60 c.c. to 255 c.c. per 24 hours. The density of the 

 urine was very changeable, generally from 1.015 to 1.035. Urea 

 was abundant owing to the large amount of meat digested by the 

 animal, and amounted to from 2.7 grams to 5.1 gramsper 100 c.c. 

 During the first few days, the urine was a little bloody. The 

 amount of albumin found was 0.50 gram and 0.25 gram for 1000 

 c.c. on two different occasions. It disappeared from the urine 

 eight days after the operation. On the thirteenth day, albumin 

 was found again, and increased progressively from traces to 1.5 

 grams and more per liter. Progressive enlargement of both kid- 

 neys was observed. Thirty days after the operation, the animal 

 became suddenly ill, and died on the thirty first day. Macros- 

 copical examination : enlargement of both kidneys due apparently 

 to a compression of the renal veins by a large organized clot 

 infiltrating the subperitoneal and perivenous connective tissue 

 between the kidneys. Microscopical examination : slight acute 

 diffuse nephritis and dilation of the blood vessels. 



