7 6 



Scientific Proceedings (28). 



proof of the success of these transplantations obtained. Such 

 proof cannot, of course, be so convincingly obtained in the cases of 

 implantation to thyroid because of the lack of certainty that no 

 parathyroid tissue except the transplanted remains at the time 

 of the final operation, at which well nourished thyroid tissue, suf- 

 ficient to insure the life of the transplanted parathyroid gland, 

 must be left. 



Isotratisplantation. — In five cases (Dogs K, L, M, N and 

 O), two, seven, five, five and eight parathyroids respectively were 

 transplanted into the spleen. In only one dog (K) was a para- 

 thyroid deficiency created. In no instance was the transplantation 

 successful ; furthermore tetany supervened and death occurred 

 just as promptly, after removal of the thyroid and parathyroids in 

 the neck, in these dogs with so many intrasplenic isografts as 

 in the ungrafted dog. Hence we may conclude that life is prob- 

 ably little, if at all, prolonged by the absorption of foreign para- 

 thyroids transplanted into the spleen. 



Second Series of Results (Winter of 1907-8). — The trans- 

 plantations were made, usually one gland at a time, at intervals of 

 from seven to ten days, behind the rectus abdominis muscle, within 

 its sheath. 



Allotransplantation. — Of eighteen autotransplantations in twelve 

 dogs, seven parathyroids were absorbed or necrotic (Dogs 3, 4, 5 

 and 10) ; five to seven lived and performed their function (Dogs 

 1, 7, 8, 9 and 11). What the fate of the four remaining glands 

 would have been (Dogs 2, 3 and 14) is doubtful, the dogs having 

 died of distemper. Four dogs are living and in good health, each, 

 presumably, with only one autograft. 



Isotransplantation. — Of twenty isotransplantations with created 

 deficiency (Dogs 7, 12, 13, 15, 16, 17, 18, 19, 20 and 24) nineteen 

 parathyroids were absorbed or necrotic. The result in one in- 

 stance remains to be determined. Dog 7, deprived of all para- 

 thyroids except the one transplanted (an autograft), lived in good 

 health and spirits twenty-five days or until at a third operation, 

 the sustaining parathyroid was removed. There was in this dog, 

 usually, a suggestion of hypoparathyroidism in a barely perceptible 

 fibrillary tremor of the tongue and of the temporal muscles. On re- 

 moval of the perfectly normal autograft behind the rectus muscle, 



